Antifungal Activity of Nanobiocomposite Films Based on Silver Nanoparticles Obtained Through Green Synthesis

被引：5

作者：

Mallmann, Eduardo Jose Juca ^{[1
]}

Cunha, Francisco Afranio ^{[1
,2
]}

Agressott, Enzo Victorino Hernandez ^{[3
]}

de Menezes, Fernando Lima ^{[1
]}

Barbosa, Rita de Cassia Carvalho ^{[2
]}

Martins, Roxeane Teles ^{[4
]}

Cunha, Maria da Conceicao dos Santos Oliveira ^{[5
,6
]}

Queiroz, Maria Veraci Oliveira ^{[5
]}

Coutinho, Henrique Douglas Melo ^{[7
]}

de Vasconcelos, John Eversong Lucena ^{[8
]}

Fechine, Pierre Basilio Almeida ^{[1
]}

机构：

[1] Univ Fed Ceara UFC, Grp Quim Mat Avancados GQMat, Dept Quim Analit & Fisicoquim, Campus Pici,CP 12100, BR-60451970 Fortaleza, CE, Brazil

[2] Univ Fed Ceara, Dept Anal Clin & Toxicol, UFC, Rua Capitao Francisco Pedro 1210, BR-60270430 Fortaleza, CE, Brazil

[3] Univ Fed Ceara UFC, Dept Fis, Campus Pici,Caixa Postal 6030, BR-60440970 Fortaleza, CE, Brazil

[4] Univ Fed Ceara, Lab Anal Clin & Toxicol, Fortaleza, Brazil

[5] Univ Estadual Ceara, Programa Posgrad Cuidados Clin Enfermagem & Saude, Fortaleza, Ceara, Brazil

[6] Fac Princesa Oeste, Crateus, Ceara, Brazil

[7] Univ Reg Cariri URCA, Dept Biol Quim, Lab Microbiol & Biol Mol, Crato, Brazil

[8] CECAPE Coll, Ave Padre Cicero 3917, BR-63024015 Sao Jose, CE, Brazil

来源：

CURRENT MICROBIOLOGY | 2023年 / 80卷 / 08期

关键词：

ANTIBACTERIAL ACTIVITY; NANOCOMPOSITE FILMS; AGAR; IMPREGNATION; ALGINATE; MATRIX;

D O I：

10.1007/s00284-023-03357-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The high incidence of Candida albicans infections has raised concerns regarding side effects and drug resistance, compounded by a limited number of alternative drugs. Silver nanoparticles (AgNPs) have prominent antimicrobial activity, but effective administration remains a challenge. In this study, AgNPs were synthesized via a green chemistry approach, using glucose as a reducing agent, and incorporated into an agar matrix to form a film (AgFilm). The AgNPs and AgFilm were characterized by Ultraviolet-visible (UV-vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), and atomic force microscopic (AFM). The UV-Vis spectra of the AgNPs and AgFilm showed bands at 415 and 413 nm, respectively. The PXRD and UV-Vis data suggest that the growth of AgNPs was effectively inhibited in the AgFilm. The diameter of AgNPs dispersed in AgFilm was 76 +/- 42 nm, and the thickness of the film and 35 +/- 3 mu m. The antifungal activity of AgFilm was evaluated against 20 strains of C. albicans, demonstrating high antifungal activity with an inhibition zone of 19 +/- 2 mm. Therefore, AgFilm could be a promising option for the treatment of superficial C. albicans infections.

引用

页数：10

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