T-Cell Receptor Repertoire Characteristics Associated with Prognostic Significance in High-Grade Serous Ovarian Carcinoma

被引：2

作者：

Kim, Ju-Won ^{[1
]}

Kim, Sewha ^{[2
,3
]}

Yang, So-Yun ^{[1
]}

Joung, Je-Gun ^{[1
,4
,5
]}

Hwang, Sohyun ^{[1
,2
,5
]}

机构：

[1] CHA Univ, Coll Life Sci, Dept Biomed Sci, Seongnam 13488, South Korea

[2] CHA Univ, CHA Bundang Med Ctr, Dept Pathol, Sch Med, Seongnam 13496, South Korea

[3] Korea Med Inst, Dept Pathol, Seoul 03173, South Korea

[4] CHA Univ, Inst Biomed Informat, Sch Med, Seongnam 13488, South Korea

[5] CHA Bundang Med Ctr, CHA Future Med Res Inst, Seongnam 13488, South Korea

来源：

GENES | 2023年 / 14卷 / 04期

关键词：

ovarian cancer; high-grade serous carcinoma; t-cell receptor; immune pathway; TUMOR-INFILTRATING LYMPHOCYTES; BIAS;

D O I：

10.3390/genes14040785

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

High-grade serous ovarian carcinoma (HGSOC) is a fatal gynecological malignancy. Somatic recombination occurring during T-cell receptor (TCR) development results in TCR diversity, and the TCR repertoire, thus produced, is associated with immune response. This study analyzed the difference in the TCR repertoire and their prognostic significance in 51 patients with HGSOC. The patient's clinical characteristics, gene expression pattern, TCR clonotypes, and degree of tumor-infiltrating leukocytes (TILs) were analyzed, and the patients were divided into groups depending on their recurrence pattern, tumor-infiltrating leukocyte (TIL) score, and homologous recombinant repair pathway deficiency (HRD)-associated mutations. The TCR repertoire was low in patients with recurrence and showed the expansion of eight TCR segments. Interestingly, a few genes correlated with the TCRs also showed a difference in expression according to the prognosis. Among them, seven genes were related to immune responses and KIAA1199 was up-regulated in ovarian cancer. Our study shows that the differences in the TCR repertoire in patients with ovarian cancer and their associated immune pathways could affect the prognosis of HGSOC.

引用

页数：12

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