Visible-Light-Enhanced Antibacterial Activity of Silver and Copper Co-Doped Titania Formed on Titanium via Chemical and Thermal Treatments

被引：6

作者：

Suzuki, Kanae ^{[1
]}

Iwatsu, Misato ^{[2
]}

Mokudai, Takayuki ^{[3
]}

Furuya, Maiko ^{[2
]}

Yokota, Kotone ^{[2
]}

Kanetaka, Hiroyasu ^{[2
]}

Shimabukuro, Masaya ^{[4
]}

Yokoi, Taishi ^{[4
]}

Kawashita, Masakazu ^{[4
]}

机构：

[1] Tohoku Univ, Grad Sch Biomed Engn, 6-6-12 Aramaki Aoba,Aoba Ku, Sendai 9808579, Japan

[2] Tohoku Univ, Grad Sch Dent, 4-1,Seiryo Machi,Aoba Ku, Sendai 9808575, Japan

[3] Tohoku Univ, Inst Mat Res, 2-1-1,Katahira,Aoba Ku, Sendai 9808577, Japan

[4] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, 2-3-10 Kanda Surugadai,Chiyoda Ku, Tokyo 1010062, Japan

来源：

MOLECULES | 2023年 / 28卷 / 02期

基金：

日本学术振兴会;

关键词：

titania; silver; copper; antibacterial activity; visible-light-responsive photocatalysis; APATITE-FORMING ABILITY; PHOTOCATALYTIC ACTIVITY; BIOACTIVE TITANIUM; TI METAL; HYDROGEN-PEROXIDE; SURFACE-STRUCTURE; PERI-IMPLANTITIS; MECHANISM; OXIDATION; AMMONIA;

D O I：

10.3390/molecules28020650

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dental implants made of titanium (Ti) are used in dentistry, but peri-implantitis is a serious associated problem. Antibacterial and osteoconductive Ti dental implants may decrease the risk of peri-implantitis. In this study, titania (TiO2) co-doped with silver (Ag) at 2.5 at.% and copper (Cu) at 4.9 at.% was formed on Ti substrates via chemical and thermal treatments. The Ag and Cu co-doped TiO2 formed apatite in a simulated body fluid, which suggests osteoconductivity. It also showed antibacterial activity against Escherichia coli, which was enhanced by visible-light irradiation. This enhancement might be caused by the synergistic effect of the release of Ag and Cu and the generation of center dot OH from the sample. Dental implants with such a Ag and Cu co-doped TiO2 formed on their surface may reduce the risk of peri-implantitis.

引用

页数：10

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