Thyroid autoimmunity and its negative impact on female fertility and maternal pregnancy outcomes

被引:26
|
作者
Tanska, Kamila [1 ]
Gietka-Czernel, Malgorzata [1 ]
Glinicki, Piotr [1 ]
Kozakowski, Jaroslaw [1 ]
机构
[1] Ctr Postgrad Med Educ, Dept Endocrinol, Warsaw, Poland
来源
FRONTIERS IN ENDOCRINOLOGY | 2023年 / 13卷
关键词
thyroid autoimmunity; female fertility; pregnancy outcomes; assisted reproductive technology outcomes; levothyroxine treatment; immunotherapy; IN-VITRO FERTILIZATION; ANTIBODY-POSITIVE WOMEN; SUBCLINICAL HYPOTHYROIDISM; INTRAVENOUS IMMUNOGLOBULIN; SELENIUM SUPPLEMENTATION; LEVOTHYROXINE TREATMENT; THYROGLOBULIN ANTIBODIES; ASSISTED REPRODUCTION; PRETERM DELIVERY; INFERTILE WOMEN;
D O I
10.3389/fendo.2022.1049665
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thyroid autoimmunity (TAI) is commonly defined as the presence of thyroperoxidase antibodies (TPOAbs) and/or thyroglobulin antibodies (TgAbs), which predisposes an individual to hypothyroidism. TAI affects nearly 10% of women of reproductive age and evokes great interest from clinicians because of its potentially negative impact on female fertility and pregnancy course. In this mini-review, we review the current literature concerning the influence of TPOAb or TPOAb/TgAb positivity without thyroid dysfunction on reproduction. TAI may negatively affect female fertility; several studies have found an increased prevalence of TAI in infertile women, especially in those with unexplained infertility and polycystic ovary syndrome. According to some observations, TAI might also be connected with premature ovarian insufficiency and endometriosis. The relationship between TAI and an increased risk of pregnancy loss is well documented. The pathophysiological background of these observations remains unclear, and researchers hypothesize on the direct infiltration of reproductive organs by thyroid antibodies, co-existence of TAI with other autoimmune diseases (either organ specific or systemic), immunological dysfunction leading to inhibition of immune tolerance, and relative thyroid hormone deficiency. Interestingly, in the current literature, better outcomes of assisted reproductive technology in women with TAI have been reported compared with those reported in earlier publications. One plausible explanation is the more widespread use of the intracytoplasmic sperm injection method. The results of randomized clinical trials have shown that levothyroxine supplementation is ineffective in preventing adverse pregnancy outcomes in women with TAI, and future research should probably be directed toward immunotherapy.
引用
收藏
页数:11
相关论文
共 50 条
  • [21] The impact of chorionicity on maternal pregnancy outcomes
    Carter, Ebony B.
    Bishop, Katherine C.
    Goetzinger, Katherine R.
    Tuuli, Methodius G.
    Cahill, Alison G.
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2015, 213 (03) : 390.e1 - 390.e7
  • [22] Thyroid dysfunction in pregnancy: optimizing fetal and maternal outcomes
    Okosieme, Onyebuchi E.
    Lazarus, John H.
    EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM, 2010, 5 (04) : 521 - 529
  • [23] The potential impact of tobacco use on female fertility and pregnancy outcomes: An invited scientific review by EBCOG
    Tsiapakidou, Sofia
    Mahmood, Tahir
    Savona-Ventura, Charles
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2023, 290 : 85 - 87
  • [24] Effect of thyroid dysfunction and autoimmunity on pregnancy outcomes in low risk population
    Kumru, Pinar
    Erdogdu, Emre
    Arisoy, Resul
    Demirci, Oya
    Ozkoral, Aysen
    Ardic, Cem
    Ertekin, Arif Aktug
    Erdogan, Sinan
    Ozdemir, Nilufer Nihan
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2015, 291 (05) : 1047 - 1054
  • [25] Thyroid autoimmunity and adverse pregnancy outcomes: A multiple center retrospective study
    Xu, Yun
    Chen, Hui
    Ren, Meng
    Gao, Yu
    Sun, Kan
    Wu, Hongshi
    Ding, Rui
    Wang, Junhui
    Li, Zheqing
    Liu, Dan
    Wang, Zilian
    Yan, Li
    FRONTIERS IN ENDOCRINOLOGY, 2023, 14
  • [26] Effect of thyroid dysfunction and autoimmunity on pregnancy outcomes in low risk population
    Pinar Kumru
    Emre Erdogdu
    Resul Arisoy
    Oya Demirci
    Aysen Ozkoral
    Cem Ardic
    Arif Aktug Ertekin
    Sinan Erdogan
    Nilufer Nihan Ozdemir
    Archives of Gynecology and Obstetrics, 2015, 291 : 1047 - 1054
  • [27] Family Support to Women During Pregnancy and Its Impact on Maternal and Fetal Outcomes
    Mane, Ujwala R.
    Salunkhe, Jyoti A.
    Kakade, Satish
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (06)
  • [28] Acute pancreatitis in pregnancy and its impact on the maternal and foetal outcomes: A systematic review
    Kumar-M, Praveen
    Singh, Anupam Kumar
    Samanta, Jayanta
    Birda, Chhagan Lal
    Kumar, Naveen
    Dhar, Jahnvi
    Gupta, Pankaj
    Kochhar, Rakesh
    PANCREATOLOGY, 2022, 22 (02) : 210 - 218
  • [29] Impact of Thyroid Autoimmunity in euthyroid women on the outcomes of In Vitro Fertilization
    Hamad, Ahed
    Alhalabi, Nawras
    Nmr, Nazht
    Abbas, Fatima
    Al-Hammami, Hisham
    Ibrahim, Nazir
    Alhalabi, Marwan
    ANNALS OF MEDICINE AND SURGERY, 2021, 67
  • [30] Impact of thyroid autoimmunity on pregnancy outcomes in euthyroid women following fresh/frozen-thawed embryo transfer
    Yang, Xiaoyan
    Qiu, Shumin
    Jiang, Wenwen
    Huang, Zhiqing
    Shi, Hang
    Du, Shengrong
    Sun, Yan
    Zheng, Beihong
    CLINICAL ENDOCRINOLOGY, 2023, 99 (01) : 113 - 121