Blood Pressure Variability and the Progression of Chronic Kidney Disease: a Systematic Review and Meta-Analysis

被引：14

作者：

Yang, Letian ^{[1
]}

Li, Jian ^{[2
]}

Wei, Wei ^{[1
]}

Pu, Yajun ^{[1
]}

Zhang, Ling ^{[1
]}

Cui, Tianlei ^{[1
]}

Ma, Liang ^{[1
]}

Wang, Bo ^{[1
]}

Zhao, Yuliang ^{[1
]}

Fu, Ping ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Kidney Res Inst, Div Nephrol, 37 Guoxue Alley, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Sch Med, Chengdu 610041, Peoples R China

来源：

JOURNAL OF GENERAL INTERNAL MEDICINE | 2023年 / 38卷 / 05期

关键词：

blood pressure variability; chronic kidney disease; end-stage renal disease; TO-VISIT VARIABILITY; TARGET-ORGAN DAMAGE; RENAL-DISEASE; CARDIOVASCULAR EVENTS; PROGNOSTIC VALUE; HEART-RATE; OUTCOMES; RISK; ASSOCIATION; NEPHROPATHY;

D O I：

10.1007/s11606-022-08001-6

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

BackgroundBlood pressure variability (BPV) is a risk factor for poor prognosis including cardiovascular events, chronic kidney disease, and mortality, independent of elevated BP.MethodsWe searched PubMed/Medline, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to November 23, 2022. Cohort studies reporting the association between BPV and chronic kidney disease (CKD) progression were selected. Hazard ratios were pooled using a random-effects model. Meta-regression, subgroup analyses, and sensitivity analyses were conducted.ResultsA total of 23 studies were included in this systematic review and meta-analysis. Increased BPV was associated with progression of CKD (HR: 1.21, 95% CI: 1.09-1.33) and incidence of ESRD (HR: 1.08, 95% CI: 1.08-1.30). Among the different BPV metrics, high variation independent of mean (VIM), coefficient of variation (CV), standard deviation (SD), and average real variability (ARV) were indicated as predictors of CKD progression.DiscussionIncreased BPV was associated with CKD progression.

引用

页码：1272 / 1281

页数：10

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