Subanesthetic Dose of Ketamine Administered Before Each Electroconvulsive Therapy Session Improves Antidepressant and Sleep Quality Outcomes

被引：3

作者：

Dong, Jun ^{[1
,3
]}

Min, Su ^{[1
]}

Chen, Qibing ^{[1
]}

Qiu, Haitang ^{[2
]}

Ren, Li ^{[1
]}

机构：

[1] Chongqing Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Chongqing, Peoples R China

[2] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China

[3] Chongqing Med Univ, Dept Anesthesiol, Affiliated Hosp 1, 1,Youyi Rd,Yuzhong Dist, Chongqing 400016, Peoples R China

来源：

JOURNAL OF ECT | 2023年 / 39卷 / 04期

关键词：

ketamine; ECT; depression; sleep disturbance; DEPRESSION; ANESTHESIA; EFFICACY; ECT;

D O I：

10.1097/YCT.0000000000000938

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Objectives The main purpose of this trial is to explore the effects of subanesthetic dose of ketamine on sleep quality and symptoms in patients with major depressive disorder undergoing bitemporal electroconvulsive therapy (ECT).Methods Seventy-one patients with major depressive disorder and sleep disturbance were randomly divided into 2 groups, namely, the ECT without ketamine group (group ES), receiving routine ECT and saline (3 mL) at each ECT session, and the ECT-assisted ketamine group (group KS), which received ECT and ketamine (3 mL) at each ECT session. The 24 Hamilton Depression Rating Scale was used to assess depressive symptoms and the Chinese Pittsburgh Sleep Quality Index was used to evaluate sleep quality.Results The patients in group KS required shorter ECT treatment sessions. Patients in group ES had lower sleep efficiency, longer sleep latency, and required more sleep medication than patients in group KS at the end of the ECT course.Conclusions Subanesthetic dose of ketamine improved sleep quality and enhanced ECT therapeutic effects in patients with sleep disturbance.

引用

页码：263 / 268

页数：6

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