Recent Advances in Palladium-Catalyzed Asymmetric Heck/Tsuji-Trost Reactions of 1,n-Dienes

Transition-metal catalyzed tandem asymmetric reactions were powerful tools to access various chiral compounds. Many strategies have been developed for the coupling of 1,n-dienes with aryl halides via a tandem Heck/Tsuji-Trost process. However, the control of regio- and stereo-chemistry remains a challenging task. This minireview details the recent advances in the field of asymmetric Heck/Tsuji-Trost reactions catalyzed by palladium complex, which have opened new opportunities and expanded our understanding in this area of research in recent years. The Pd-catalyzed asymmetric tandem Heck/Tsuji-Trost reaction provided a powerful method for the preparation of various chiral compounds containing an allylic moiety. Chiral palladium/phosphine complex efficiently promoted a wide range of difunctionalization of 1,n-dienes (n=2-4) for constructing C-C and C-X (X=C, O, N) bond simultaneously. This review summarizes the recent advances in this field and highlights the significant achievements. image