Prodrugs of Nucleotide Analogues

被引:0
作者
Kalcic, F. [1 ]
机构
[1] Swiss Fed Inst Technol, Vladimir Prelog Weg 3, CH-8093 Zurich, Switzerland
来源
CHEMICKE LISTY | 2024年 / 118卷 / 01期
关键词
prodrugs; nucleotides; nucleosides; phosphates; phosphonates; bioavailability; TENOFOVIR ALAFENAMIDE; PHOSPHONATE PRODRUGS; PHOSPHORAMIDATE DERIVATIVES; PROTIDE PRODRUGS; HEPATITIS-B; NUCLEOSIDE; DESIGN; DRUGS; STABILITY; ESTERS;
D O I
10.54779/chl20240003
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The field of medicinal chemistry is often struggling with suboptimal properties of active compounds. To address this issue, many sophisticated prodrug approaches have been developed. Prodrug is an inactive form of a drug which temporarily alters its properties. In the body, the prodrug is (most often enzymatically) transformed back to the parent active drug. Prodrugs can modify variety of properties such as absorption, solubility, or tissue targeted delivery. The number of prodrugs among approved drugs has been rising in the past years which underlines the importance of prodrugs for medicinal chemistry and clinical use.
引用
收藏
页码:3 / 11
页数:9
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