Clinicopathological characteristics of 3 probable pediatric cases with acute severe hepatitis of unknown aetiology

被引：1

作者：

Li, Meiling ^{[1
]}

Jiang, Lina ^{[1
]}

Liu, Shuhong ^{[1
]}

Xu, Pengfei ^{[1
]}

Wei, Haiyan ^{[1
]}

Li, Yu ^{[1
]}

Guo, Chaonan ^{[1
]}

Zhu, Li ^{[1
]}

Zhao, Bokang ^{[2
]}

Liu, Yisi ^{[3
]}

Zhang, Min ^{[1
,4
]}

Zhao, Jingmin ^{[1
,4
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Beijing, Peoples R China

[2] First Hosp Jilin Univ, Ctr Infect Dis & PathogenBiol, Dept Hepatol, Changchun, Peoples R China

[3] Capital Med Univ, Beijing Youan Hosp, Dept Liver Dis Ctr 1, Beijing, Peoples R China

[4] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, 100 Xisihuan Middle Rd, Beijing 100039, Peoples R China

来源：

NEW MICROBES AND NEW INFECTIONS | 2024年 / 56卷

基金：

北京市自然科学基金;

关键词：

Acute severe hepatitis; Unknown aetiology; Children; Clinicopathological characteristics; CHILDREN; VIRUS;

D O I：

10.1016/j.nmni.2023.101203

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Acute severe hepatitis with unknown aetiology in children (ASHep-UA) has become a global health alert. This article reported clinicopathological characteristics of 3 probable ASHep-UA cases.Methods: We respectively collected serological data and liver biopsies of 3 suspected cases of ASHep-UA. Neutralizing antibodies titer for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants were determined by virus neutralization test (VNT). Histological assessment, immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) for cytomegalovirus (CMV), Epstein-Barr virus (EBV), human adenoviruses (HAdV), adeno-associated virus (AAV2), human herpes virus type 6 (HHV-6) were performed to identify possible aetiologies.Results: Remarkable elevation of transaminase (median ALT level, 1100 IU/liter; median AST level, 500 IU/liter) were revealed with undetectable hepatitis A-E and non-hepatotropic virus in both sera and tissues. Weakness, jaundice, pale stools and splenomegaly were observed. Interestingly, two individuals had SARS-CoV-2 Omicron variants infection. Histologically, moderate or severe lobular necroinflammation, active interface hepatitis and portal inflammatory infiltrate with lymphocytic, plasma cells, neutrophils and eosinophilic cells were noted.Conclusions: The exact aetiology of ASHep-UA was still unknown. By reporting the 3 probable cases, we expect to enrich the clinical experience in diagnosis and treatment of ASHep-UA as well as the pathological characteristics.

引用

页数：5

共 42 条

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