Circadian clock and lipid metabolism disorders: a potential therapeutic strategy for cancer

被引:11
作者
Liu, Mengsi [1 ,2 ,3 ,4 ]
Zhang, Zhen [5 ]
Chen, Yating [1 ,2 ,3 ,4 ]
Feng, Ting [1 ,2 ,3 ,4 ]
Zhou, Qing [6 ]
Tian, Xuefei [1 ,2 ,3 ,4 ]
机构
[1] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha, Hunan, Peoples R China
[2] Hunan Univ Chinese Med, Hunan Key Lab Tradit Chinese Med Prescript & Syndr, Changsha, Peoples R China
[3] Hunan Prov Univ Key Lab Oncol Tradit Chinese Med, Changsha, Peoples R China
[4] Hunan Univ Chinese Med, Key Lab Tradit Chinese Med Mech Tumor Prevent & Tr, Changsha, Peoples R China
[5] Hunan Acad Tradit Chinese Med, Dept Oncol, Affiliated Hosp, Changsha, Peoples R China
[6] Hunan Univ Chinese Med, Dept Androl, Affiliated Hosp 1, Changsha, Peoples R China
基金
中国国家自然科学基金;
关键词
circadian clock; lipid metabolism; cancer; fatty acid synthetic; SREBP; FATTY-ACID SYNTHASE; REV-ERB-ALPHA; ATP-CITRATE LYASE; CELL LUNG-CANCER; COA-DESATURASE; PROLIFERATOR-ACTIVATED RECEPTORS; HELIX TRANSCRIPTION FACTOR; ELEMENT-BINDING PROTEIN-1; INDUCED APOPTOTIC PATHWAY; ENDOMETRIAL TUMOR-GROWTH;
D O I
10.3389/fendo.2023.1292011
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Recent research has emphasized the interaction between the circadian clock and lipid metabolism, particularly in relation to tumors. This review aims to explore how the circadian clock regulates lipid metabolism and its impact on carcinogenesis. Specifically, targeting key enzymes involved in fatty acid synthesis (SREBP, ACLY, ACC, FASN, and SCD) has been identified as a potential strategy for cancer therapy. By disrupting these enzymes, it may be possible to inhibit tumor growth by interfering with lipid metabolism. Transcription factors, like SREBP play a significant role in regulating fatty acid synthesis which is influenced by circadian clock genes such as BMAL1, REV-ERB and DEC. This suggests a strong connection between fatty acid synthesis and the circadian clock. Therefore, successful combination therapy should target fatty acid synthesis in addition to considering the timing and duration of drug use. Ultimately, personalized chronotherapy can enhance drug efficacy in cancer treatment and achieve treatment goals
引用
收藏
页数:19
相关论文
共 50 条
[31]   Molecular crosstalk between circadian clock and cancer and therapeutic implications [J].
Qu, Meng .
FRONTIERS IN NUTRITION, 2023, 10
[32]   Preventive Effect of L-Carnitine on the Disorder of Lipid Metabolism and Circadian Clock of Mice Subjected to Chronic Jet-Lag [J].
Xie, Xiaoxian ;
Guo, Anqi ;
Wu, Tao ;
Hu, Qinglian ;
Huang, Liangfeng ;
Yao, Cencen ;
Zhao, Binggong ;
Zhang, Wanjing ;
Chi, Bingbing ;
Lu, Ping ;
Zhao, Zhenzhen ;
Fu, Zhengwei .
PHYSIOLOGICAL RESEARCH, 2017, 66 (05) :801-810
[33]   Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock [J].
Dyar, Kenneth Allen ;
Hubert, Michael Jean ;
Mir, Ashfaq Ali ;
Ciciliot, Stefano ;
Lutter, Dominik ;
Greulich, Franziska ;
Quagliarini, Fabiana ;
Kleinert, Maximilian ;
Fischer, Katrin ;
Eichmann, Thomas Oliver ;
Wright, Lauren Emily ;
Paz, Marcia Ivonne Pena ;
Casarin, Alberto ;
Pertegato, Vanessa ;
Romanello, Vanina ;
Albiero, Mattia ;
Mazzucco, Sara ;
Rizzuto, Rosario ;
Salviati, Leonardo ;
Biolo, Gianni ;
Blaauw, Bert ;
Schiaffino, Stefano ;
Uhlenhaut, N. Henriette .
PLOS BIOLOGY, 2018, 16 (08)
[34]   The Role of Lipid Metabolism Disorders in the Development of Thyroid Cancer [J].
Lukasiewicz, Martyna ;
Zwara, Agata ;
Kowalski, Jacek ;
Mika, Adriana ;
Hellmann, Andrzej .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (13)
[35]   Nuclear membrane: A key potential therapeutic target for lipid metabolism [J].
Zeng, Min ;
Chen, Longgui ;
Wang, Yazhu .
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2024, 194 :10-15
[36]   Hepatocellular carcinoma and lipid metabolism: Novel targets and therapeutic strategies [J].
Cao, Lu-Qi ;
Xie, Yuhao ;
Fleishman, Joshua S. ;
Liu, Xuan ;
Chen, Zhe-Sheng .
CANCER LETTERS, 2024, 597
[37]   Evaluation of small-molecule modulators of the circadian clock: promising therapeutic approach to cancer [J].
Tavsanli, Nalan ;
Erozden, Ahmet Arihan ;
Caliskan, Mahmut .
MOLECULAR BIOLOGY REPORTS, 2024, 51 (01)
[38]   Circadian clock dysfunction in Parkinson's disease: mechanisms, consequences, and therapeutic strategy [J].
Yalcin, Muege ;
Grande, Valentina ;
Outeiro, Tiago Fleming ;
Relogio, Angela .
NPJ PARKINSONS DISEASE, 2025, 11 (01)
[39]   Circadian clock: a regulator of the immunity in cancer [J].
Zhen Zhang ;
Puhua Zeng ;
Wenhui Gao ;
Qing Zhou ;
Ting Feng ;
Xuefei Tian .
Cell Communication and Signaling, 19
[40]   Potential Roles of Dec and Bmal1 Genes in Interconnecting Circadian Clock and Energy Metabolism [J].
Sato, Fuyuki ;
Kohsaka, Akira ;
Bhawal, Ujjal K. ;
Muragaki, Yasuteru .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (03)