Circadian clock and lipid metabolism disorders: a potential therapeutic strategy for cancer

被引：11

作者：

Liu, Mengsi ^{[1
,2
,3
,4
]}

Zhang, Zhen ^{[5
]}

Chen, Yating ^{[1
,2
,3
,4
]}

Feng, Ting ^{[1
,2
,3
,4
]}

Zhou, Qing ^{[6
]}

Tian, Xuefei ^{[1
,2
,3
,4
]}

机构：

[1] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha, Hunan, Peoples R China

[2] Hunan Univ Chinese Med, Hunan Key Lab Tradit Chinese Med Prescript & Syndr, Changsha, Peoples R China

[3] Hunan Prov Univ Key Lab Oncol Tradit Chinese Med, Changsha, Peoples R China

[4] Hunan Univ Chinese Med, Key Lab Tradit Chinese Med Mech Tumor Prevent & Tr, Changsha, Peoples R China

[5] Hunan Acad Tradit Chinese Med, Dept Oncol, Affiliated Hosp, Changsha, Peoples R China

[6] Hunan Univ Chinese Med, Dept Androl, Affiliated Hosp 1, Changsha, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

circadian clock; lipid metabolism; cancer; fatty acid synthetic; SREBP; FATTY-ACID SYNTHASE; REV-ERB-ALPHA; ATP-CITRATE LYASE; CELL LUNG-CANCER; COA-DESATURASE; PROLIFERATOR-ACTIVATED RECEPTORS; HELIX TRANSCRIPTION FACTOR; ELEMENT-BINDING PROTEIN-1; INDUCED APOPTOTIC PATHWAY; ENDOMETRIAL TUMOR-GROWTH;

D O I：

10.3389/fendo.2023.1292011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent research has emphasized the interaction between the circadian clock and lipid metabolism, particularly in relation to tumors. This review aims to explore how the circadian clock regulates lipid metabolism and its impact on carcinogenesis. Specifically, targeting key enzymes involved in fatty acid synthesis (SREBP, ACLY, ACC, FASN, and SCD) has been identified as a potential strategy for cancer therapy. By disrupting these enzymes, it may be possible to inhibit tumor growth by interfering with lipid metabolism. Transcription factors, like SREBP play a significant role in regulating fatty acid synthesis which is influenced by circadian clock genes such as BMAL1, REV-ERB and DEC. This suggests a strong connection between fatty acid synthesis and the circadian clock. Therefore, successful combination therapy should target fatty acid synthesis in addition to considering the timing and duration of drug use. Ultimately, personalized chronotherapy can enhance drug efficacy in cancer treatment and achieve treatment goals

引用

页数：19

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