The Functional Mechanisms of Toll-Like Receptor 3 and Its Implications in Digestive System Tumors

被引：3
作者：
Han, Bin [1 ,2 ]
Zhang, Chao [1 ,2 ]
Wang, Xiaoxiao [1 ,2 ]
Song, Huangqin [1 ,2 ]
Zhang, Lei [2 ,3 ]
Li, Tao [4 ]
He, Jiefeng [1 ,2 ]
Zhao, Haoliang [1 ,2 ]
机构：
[1] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Hosp 3, Taiyuan 030032, Shanxi, Peoples R China
[2] Shanxi Acad Med Sci, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Dept Hepatobiliary Surg, Taiyuan 030032, Shanxi, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Hepatopancreatobiliary Surg, Tongji Med Coll,Hepat Surg Ctr, Wuhan 430030, Hubei, Peoples R China
[4] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Surg, Wuhan 430022, Hubei, Peoples R China
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2023年 / 28卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Toll-like receptor 3; digestive system tumors; dsRNA; TLR3; agonist; DOUBLE-STRANDED-RNA; NF-KAPPA-B; HEPATOCELLULAR-CARCINOMA; TLR3; AGONIST; TRIGGERS APOPTOSIS; MYELOID CELLS; ACTIVATION; EXPRESSION; PATHWAYS; INFLAMMATION;
D O I：
10.31083/j.fbl2811297
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Toll-like receptor 3 (TLR3) is a prominent member of the Toll-like receptor (TLR) family and has the ability to recognize and bind intracellular double-stranded RNA (dsRNA). Once triggered by a viral infection or other pathological condition, TLR3 activates immune cells and induces the production of interferons and other immune response molecules. Additionally, TLR3 is considered an important immune modulator, as it can regulate cell apoptosis and promote anticancer immunity. The investigation and application of TLR3 agonists in digestive system tumors have attracted widespread attention and are regarded as a promising cancer treatment strategy with potential clinical applications. TLR3 expression levels are generally elevated in most digestive system tumors, and higher TLR3 expression is associated with a better prognosis. Therefore, TLR3 has emerged as a novel therapeutic target for digestive system tumors. It has been used in combination with chemotherapy, radiotherapy, and targeted therapy and demonstrated excellent efficacy and tolerability. This has provided new ideas and hopes for the treatment of digestive system tumors. This review discusses the mechanisms of TLR3 and its frontier research in digestive system tumors.
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页数：15
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