Development of prevalence and incidence of non-tuberculous mycobacteria in German laboratories from 2016 to 2020

被引:3
作者
Corbett, Caroline [1 ]
Finger, Philipp [1 ]
Heiss-Neumann, Marion [2 ]
Bohnert, Juergen [3 ]
Eder, Ines B. [4 ]
Eisele, Melanie [5 ]
Friesen, Inna [6 ]
Kaasch, Achim J. [7 ,8 ]
Kehrmann, Jan [9 ]
Lang, Roland [10 ]
Roedel, Juergen [11 ]
Roessler, Susann [12 ]
Schmidt, Annika [13 ]
Schneitler, Sophie [14 ,15 ]
Schui, Daniela [16 ]
Schuler, Franziska [17 ]
Sedlacek, Ludwig [18 ]
Serr, Annerose [19 ]
Sitaru, Ana-Gabriela [20 ]
Steinmann, Joerg [21 ]
Wagner, Dirk [22 ]
Wichelhaus, Thomas A. [23 ]
Hofmann-Thiel, Sabine [1 ,24 ]
Hoffmann, Harald [1 ,24 ]
机构
[1] WHO Supranat TB Reference Lab, Dept IML red GmbH, Inst Microbiol & Lab Med, Robert Koch Allee 2, D-82131 Munich, Germany
[2] German Ctr Lung Res Gauting, Asklepios Lung Clin Munich Gauting, Dep Pneumol & Infect Dis, Gauting, Germany
[3] Friedrich Loeffler Inst Med Microbiol, Greifswald, Germany
[4] Univ Hosp Leipzig, Inst Med Microbiol & Virol, Leipzig, Germany
[5] Univ Med Gottingen, Inst Med Mikrobiol, Gottingen, Germany
[6] Labor Berlin Charite Vivantes GmbH, Berlin, Germany
[7] Otto von Guericke Univ, Inst Med Microbiol, Magdeburg, Germany
[8] Otto von Guericke Univ, Hosp Hyg, Fac Med, Magdeburg, Germany
[9] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Microbiol, Essen, Germany
[10] Univ Klinikum Erlangen, Inst Klin Mikrobiol Immunol & Hyg, Erlangen, Germany
[11] Friedrich Schiller Univ, Inst Med Microbiol, Jena Univ Hosp, Jena, Germany
[12] Tech Univ Dresden, Univ Klinikum Carl Gustav Carus, Inst Med Mikrobiol & Virol, Dresden, Germany
[13] Inst Med Mikrobiol & Hyg, Tubingen, Germany
[14] Saarland Univ, Inst Med Microbiol & Hyg, Homburg, Germany
[15] Univ Cologne, Clin Pneumol & Allergol, Bethanien Hosp, Inst Pneumol,Ctr Sleep Med & Resp Care, Solingen, Germany
[16] Biosc Inst Med Diagnost GmbH, Mikrobiol, Ingelheim, Germany
[17] Univ Hosp, Inst Med Microbiol, Munster, Germany
[18] Hannover Med Sch, Inst Med Microbiol & Hosp Epidemiol, Hannover, Germany
[19] Univ Freiburg, Inst Med Microbiol & Hyg, Freiburg, Germany
[20] Med Versogungszentrum Clotten, Freiburg, Germany
[21] Paracelsus Med Univ, Inst Clin Microbiol Infect Dis & Infect Control, Klinikum Nurnberg, Nurnberg, Germany
[22] Univ Freiburg, Dept Internal Med 2, Div Infect Dis, Med Ctr,Fac Med, Freiburg, Germany
[23] Univ Hosp Frankfurt, Inst Med Microbiol & Infect Control, Frankfurt, Germany
[24] SYNLAB MVZ Dachau GmbH, SYNLAB Gauting, Munich, Germany
关键词
Non-tuberculous mycobacteria; prevalence; incidence; drug susceptibility; NTM-pulmonary disease; PULMONARY-DISEASE; EPIDEMIOLOGY; DIAGNOSIS;
D O I
10.1080/22221751.2023.2276342
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Numbers of non-tuberculous mycobacteria (NTM) pulmonary diseases (PD) have been repeatedly reported as increasing over the last decades, particularly in Europe. Sound epidemiological data are however missing for most European regions. This study calculated prevalence and incidence of NTM recovered from patients' lungs in Germany, the largest Central European country, over a five-year period. It furthermore determined regional particularities of NTM species and results from susceptibility testing. 22 German NTM laboratories provided their mycobacteriological diagnostic data of 11,430 NTM isolates recovered from 5998 pulmonary patients representing 30% of all notified NTM-PD cases of Germany from 2016 to 2020. NTM incidence and prevalence were calculated for every study year. The presented epidemiological indicators are particularly reliant as TB surveillance data were used as a reference and TB notification reaches almost 100% in Germany. Laboratory incidence and prevalence of NTM recovered from respiratory samples ranged from 4.5-4.9 and from 5.3-5.8/100,000 for the population of Germany, respectively, and did not change over the five-year study period. Prevalence and incidence were stable also when stratifying for facultative pathogenic NTM, M. avium/intracellulare complex (MAIC), and M. abscessus/chelonae complex (MABSC). The proportion of NTM with drug susceptibility testing (DST) increased from 27.3% (2016) to 43.8% (2020). The unchanging laboratory NTM prevalence/incidence in Germany represents a "ceiling" of possible NTM-PD notification when diagnostic strategies do not change in the coming years. A notable increase in NTM-DST may indicate better notification of NTM-PD and/or awareness of new clinical guidelines but still remains below clinical needs.
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页数:12
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