The aim of this letter to the editor is to discuss the influence of SARS-CoV-2 infection on the progression of sporadic Creutzfeldt-Jakob disease (sCJD). A 73-year-old male was diagnosed with sCJD based on the clinical presentation, cerebral MRI, FDG-PET, and elevated 14-3-3 in cerebrospinal fluid. One month earlier he had suffered a slight COVID-19 infection. It was concluded that COVID-19 can lead to accelerated pathogenesis and exaggerated manifestations of sCJD.