Long-term exposure to PM2.5 compositions and O3 and their interactive effects on DNA methylation of peripheral brain-derived neurotrophic factor promoter

被引：6

作者：

Huang, Haoyu ^{[1
]}

Xie, Bing ^{[2
,3
]}

Liu, Yuewei ^{[4
]}

Dong, Guang-Hui ^{[1
]}

Liu, Ruqing ^{[1
]}

Gui, Zhaohuan ^{[1
]}

Chen, Lijun ^{[5
]}

Li, Shanshan ^{[6
]}

Guo, Yuming ^{[6
]}

Yang, Lei ^{[7
,8
]}

Chen, Gongbo ^{[6
,9
]}

机构：

[1] Sun Yat Sen Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Guangzhou, Peoples R China

[2] Hebei Med Univ, Coll Forens Med, Shijiazhuang, Peoples R China

[3] Chinese Acad Med Sci, Collaborat Innovat Ctr Forens Med Mol Identificat, Res Unit Digest Tract Microecosyst Pharmacol & Tox, Hebei Key Lab Forens Med, Shijiazhuang, Peoples R China

[4] Sun Yat Sen Univ, Sch Publ Hlth, Dept Epidemiol, Guangzhou, Peoples R China

[5] Hubei Univ Chinese Med, Coll Informat Engn, Wuhan, Peoples R China

[6] Monash Univ, Sch Publ Hlth & Prevent Med, Air Qual Res Unit, Climate, Melbourne, Australia

[7] Hebei Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hebei Key Lab Environm & Human Hlth, Shijiazhuang, Peoples R China

[8] Hebei Med Univ, Hebei Key Lab Environm & Human Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, Shijiazhuang 050017, Peoples R China

[9] Monash Univ, Sch Publ Hlth & Prevent Med, Air Qual Res Unit, Climate, Melbourne 3004, Australia

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH | 2024年 / 34卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Particulate matter; sulfate; ozone; BDNF promoter; DNA methylation; AMBIENT PM2.5; BDNF; PREVALENCE; BIOMARKER;

D O I：

10.1080/09603123.2023.2280157

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study examined the associations of long-term exposure to ambient fine particulate matter (PM2.5) compositions/ozone with methylation of peripheral brain-derived neurotrophic factor (BDNF) promoters. A total of 101 participants were recruited from a cohort in Shijiazhuang, Hebei province, China. They underwent baseline and follow-up surveys in 2011 and 2015. DNA methylation levels were detected by bisulfite-PCR amplification and pyrosequencing. Participants' three-year average levels of PM2.5 compositions and ozone were estimated. Bayesian kernel machine regression (BKMR) models were used to examine the joint effects of pollutants on methylation levels. Exposure to PM2.5 compositions and ozone mixtures at the 75th percentile was associated with increased methylation levels at CpG2 of BDNF promoter (203%, 95% CI: 89, 316) than the lowest level of exposure, and sulfate dominated the effect in the BKMR models.Our findings provide clues to the epigenetic mechanisms for the associations of PM2.5 compositions and ozone with BDNF.

引用

页码：2957 / 2968

页数：12

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