Fibroblast growth factor 23 and its role in bone diseases

被引:2
|
作者
Jurina, Andrija [1 ]
Kasumovic, Dino [2 ]
Delimar, Valentina [3 ,7 ]
Filipec Kanizaj, Tajana [4 ,5 ]
Japjec, Mladen [1 ]
Dujmovic, Tomislav [1 ]
Vucic Lovrencic, Marijana [6 ]
Staresinic, Mario [1 ,5 ]
机构
[1] Merkur Univ Hosp, Dept Surg, Div Gen & Sport Traumatol & Orthopaed, Zagreb, Croatia
[2] Dubrava Univ Hosp, Dept Internal Med, Div Nephrol & Dialysis, Zagreb, Croatia
[3] Special Hosp Med Rehabil KrapinskeToplice, Krapinsketoplice, Croatia
[4] Merkur Univ Hosp, Dept Internal Med, Div Gastroenterol, Zagreb, Croatia
[5] Univ Zagreb, Sch Med, Zagreb, Croatia
[6] Merkur Univ Hosp, Dept Clin Chem & Lab Med, Zagreb, Croatia
[7] Special Hosp Med Rehabil KrapinskeToplice, Gajeva 2, Krapinsketoplice 49217, Croatia
关键词
Fibroblast growth factor; FGF23; hypophosphatemic diseases; osteoporosis; fragility fractures; chronic liver disease; chronic kidney disease; MINERAL DENSITY; HYPOPHOSPHATEMIC RICKETS; PARATHYROID-HORMONE; FRACTURE RISK; FGF23; KIDNEY; FIBROBLAST-GROWTH-FACTOR-23; MEN; DETERMINANTS; FRAGILITY;
D O I
10.1080/08977194.2023.2274579
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Fibroblast growth factor 23 (FGF23) has been casually linked to numerous hypophosphatemic bone diseases, however connection with bone loss or fragility fractures is still a matter of debate. The purpose of this review is to explore and summarise the known actions of FGF23 in various pathological bone conditions. Besides implication in bone mineralisation, elevated FGF23 showed a pathological effecton bone remodelling, primarily by inhibiting osteoblast function. Unlike the weak association with bone mineral density, high values of FGF23 have been connected with fragility fracture prevalence. This review shows that its effects on bone are concomitantly present on multiple levels, affecting both qualitative and quantitative part of bone strength, eventually leading to impaired bone strength and increased tendency of fractures. Recognising FGF23 as a risk factor for the development of bone diseases and correcting its levels could lead to the reduction of morbidity and mortality in specific groups of patients.
引用
收藏
页码:1 / 12
页数:12
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