Undescribed steroidal alkaloids from the bulbs of Fritillaria sinica

被引：3

作者：

Li, Jia-yuan ^{[1
]}

Wu, Shi-fei ^{[1
]}

An, Ya-ling ^{[1
,2
]}

Yao, Chang-liang ^{[1
]}

Yao, Shuai ^{[1
]}

Huang, Yong ^{[1
]}

Wei, Wen -long ^{[1
]}

Zhang, Jian-qing ^{[1
]}

Bi, Qi-rui ^{[1
]}

Qu, Hua ^{[1
]}

Guo, De-an ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, 501 Haike Rd, Shanghai 201203, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

PHYTOCHEMISTRY | 2023年 / 213卷

基金：

中国国家自然科学基金;

关键词：

Fritillaria sinica; Liliaceae; Zhonghuabeimu; Steroidal alkaloid derivatives; Anti -cancer effect; Anti; -oxidation; -inflammation; ISOSTEROIDAL ALKALOIDS; ELUCIDATION;

D O I：

10.1016/j.phytochem.2023.113768

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eight undescribed steroidal alkaloid derivatives, including three cevanine-type isosteroidal alkaloids (two N -oxide glycosides and one D-ring aromatization) (1-3), one verazine-type steroidal alkaloid derivative (4), three solanidine-type steroidal alkaloid glycosides (5-7), and one veratramine-type analogue (8), along with three known compounds (9-11) were isolated from the bulbs of Fritillaria sinica. Their structures were elucidated by comprehensive analysis of spectroscopic data, acidic hydrolysis, and X-ray crystal diffractions. In the in vitro bioassay, the anti-cancer effect, anti-oxidation and anti-inflammatory activities for the isolates were evaluated at a concentration of 10 & mu;M.

引用

页数：11

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