Undescribed steroidal alkaloids from the bulbs of Fritillaria sinica

被引：3
|
作者：
Li, Jia-yuan [1 ]
Wu, Shi-fei [1 ]
An, Ya-ling [1 ,2 ]
Yao, Chang-liang [1 ]
Yao, Shuai [1 ]
Huang, Yong [1 ]
Wei, Wen -long [1 ]
Zhang, Jian-qing [1 ]
Bi, Qi-rui [1 ]
Qu, Hua [1 ]
Guo, De-an [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, 501 Haike Rd, Shanghai 201203, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
PHYTOCHEMISTRY | 2023年 / 213卷
基金：
中国国家自然科学基金;
关键词：
Fritillaria sinica; Liliaceae; Zhonghuabeimu; Steroidal alkaloid derivatives; Anti -cancer effect; Anti; -oxidation; -inflammation; ISOSTEROIDAL ALKALOIDS; ELUCIDATION;
D O I：
10.1016/j.phytochem.2023.113768
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eight undescribed steroidal alkaloid derivatives, including three cevanine-type isosteroidal alkaloids (two N -oxide glycosides and one D-ring aromatization) (1-3), one verazine-type steroidal alkaloid derivative (4), three solanidine-type steroidal alkaloid glycosides (5-7), and one veratramine-type analogue (8), along with three known compounds (9-11) were isolated from the bulbs of Fritillaria sinica. Their structures were elucidated by comprehensive analysis of spectroscopic data, acidic hydrolysis, and X-ray crystal diffractions. In the in vitro bioassay, the anti-cancer effect, anti-oxidation and anti-inflammatory activities for the isolates were evaluated at a concentration of 10 & mu;M.
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页数：11
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