Mitochondria-targeted fluorophores for in vivo NIR-II imaging-guided PDT/PTT

被引：23
|
作者：
Ding, Qihang [1 ]
Mei, Ling [4 ]
Liu, Yu [2 ,3 ]
Zhou, Shan [2 ,3 ]
Chen, Lu [2 ,3 ]
Liang, Yuying [2 ,3 ]
Li, Mingle [1 ]
Zhou, Hui [2 ,3 ]
Yin, Chao [2 ,3 ]
Kim, Jong Seung [1 ]
机构：
[1] Korea Univ, Dept Chem, Seoul 02841, South Korea
[2] Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, State Key Lab Organ Elect & Informat Displays, 9 Wenyuan Rd, Nanjing 210023, Peoples R China
[3] Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, 9 Wenyuan Rd, Nanjing 210023, Peoples R China
[4] Chengdu Univ, Sichuan Ind Inst Antibiot, Engn Res Ctr Pharmaceut & Equipment Sichuan Prov, Sch Pharm, Chengdu 610106, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 52期
基金：
新加坡国家研究基金会; 中国国家自然科学基金;
关键词：
PHOTODYNAMIC THERAPY;
D O I：
10.1039/d3cc02380j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple yet powerful D-A type-based NIR-II fluorophore (MTF) with mitochondria targeting was constructed. This mitochondrial targeting dye MTF exhibited not only a photothermal effect but also photodynamic performance, and was further fabricated with DSPE-mPEG to generate nanodots for in vivo experiments, achieving strong NIR-II fluorescence tracing of tumors and impressive NIR-II image-guided photodynamic therapy (PDT) and photothermal therapy (PTT).
引用
收藏
页码：8127 / 8130
页数：4
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