Challenges in the pharmacological treatment of patients under suspicion of chronic traumatic encephalopathy: A review

被引：0
|
作者：
Kawamura, Lorena Roberta de Souza Mendes [1 ,3 ]
Mota, Isabela Ferreira Lima [1 ]
Vasconcelos, Amanda Santos [2 ]
Mortari, Marcia Renata [1 ]
机构：
[1] Univ Brasilia, Inst Biol Sci, Dept Physiol Sci, Neuropharmacol Lab, Brasilia, Brazil
[2] Univ Brasilia, Biol Sci, Brasilia, Brazil
[3] Univ Brasilia, Inst Biol Sci, Dept Physiol Sci, Campus Univ Darcy Ribeiro, Brasilia, DF, Brazil
来源：
BRAIN RESEARCH | 2023年 / 1799卷
关键词：
Chronic traumatic encephalopathy; Punch drunk; Dementia pugilistica; Head injury; BLOOD-BRAIN-BARRIER; ALZHEIMERS-DISEASE; NEUROFIBRILLARY TANGLES; DEMENTIA-PUGILISTICA; CEREBRAL-CORTEX; MOUSE MODEL; INJURY; LITHIUM; DIAGNOSIS; NEURODEGENERATION;
D O I：
10.1016/j.brainres.2022.148176
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Chronic traumatic encephalopathy (CTE) is caused by progressive neurodegeneration associated with repetitive head impacts. This disease is more common in professionals who practice contact sports, resulting in a concussion and subconcussive trauma. CTE is characterized by the accumulation of hyperphosphorylated tau protein in neurons, astrocytes, and frontotemporal lobe degeneration. Symptoms are usually nonspecific and overlap with other neurodegenerative diseases, such as Alzheimer's disease and frontotemporal dementia, making it difficult to provide drug treatment for patients with this comorbidity. Therefore, the objective of this article is to present an updated review of the pharmacological treatment of chronic traumatic encephalopathy and its challenges.
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页数：9
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