P2X7-dependent immune pathways in retinal diseases

被引：10

作者：

Dechelle-Marquet, Paul-Alexandre ^{[1
]}

Guillonneau, Xavier ^{[1
]}

Sennlaub, Florian ^{[1
]}

Delarasse, Cecile ^{[1
]}

机构：

[1] Sorbonne Univ, Inst Vis, INSERM, CNRS, 17 Rue Moreau, F-75012 Paris, France

来源：

NEUROPHARMACOLOGY | 2023年 / 223卷

关键词：

Retina; Age-related macular degeneration; Uveitis; Macrophage; Microglia; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PURINERGIC P2X7 RECEPTOR; EXTRACELLULAR ATP; NLRP3; INFLAMMASOME; P2X(7); RELEASE; CELLS; MICROGLIA; ACTIVATION; PHAGOCYTES;

D O I：

10.1016/j.neuropharm.2022.109332

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adenosine triphosphate (ATP) is a signalling molecule acting as a neurotransmitter but also as a danger signal. The purinergic receptor P2X7 is the main sensor of high concentration of ATP released by damaged cells. In the eye, P2X7 is expressed by resident microglia and immune cells that infiltrate the retina in disease such as age -related macular degeneration (AMD), a degenerative retinal disease, and uveitis, an inflammatory eye disease. Activation of P2X7 is involved in several physiological and pathological processes: phagocytosis, activation of the inflammasome NLRP3, release of pro-inflammatory mediators and cell death. The aim of this review is to discuss the potential involvement of P2X7 in the development of AMD and uveitis.

引用

页数：5

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