Greater bone marrow fat and myosteatosis are associated with lower vBMD but not asymptomatic vertebral fracture

被引:6
作者
Wang, Ling [1 ]
Li, Sidong [2 ]
Liu, Yandong [1 ]
Li, Kai [1 ]
Yin, Lu [3 ]
Su, Yongbin [1 ]
Guo, Zhe [1 ]
Xu, Li [1 ]
Huang, Pengju [1 ]
Geng, Jian [1 ]
Zhang, Wenshuang [1 ]
Ma, Kangkang [1 ]
Cheng, Kebin [1 ]
Yan, Dong [1 ]
Blake, Glen M. [4 ]
He, Bo [5 ]
Liu, Yajun [6 ]
Cheng, Xiaoguang [1 ]
机构
[1] Beijing Jishuitan Hosp, Dept Radiol, Beijing, Peoples R China
[2] Univ Sci & Technol China, Div Life Sci & Med, Hefei, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Med Res & Biometr Ctr, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China
[4] Kings Coll London, Sch Biomed Engn & Imaging Sci, St Thomas Hosp, London, England
[5] Kunming Med Univ, Dept Radiol, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China
[6] Beijing Jishuitan Hosp, Dept Spine Surg, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
Bone marrow fat; Myosteatosis; Body composition; Cancellous bone density; Vertebral fracture; BMD;
D O I
10.1007/s00330-022-08979-x
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objectives Organ fat may affect bone metabolism and be associated with vertebral fracture (VF). This study aimed to explore relationships between VF, adiposity indexes measured by MRI, and volumetric BMD (vBMD) measured by quantitative CT (QCT). Methods Four hundred volunteers, ranging in age from 22 to 83 years, were recruited and underwent same-day abdominal QCT and chemical shift-encoded (CSE) MRI. We used MRI to quantify the fat content of bone marrow (BMF), psoas major and paraspinal muscles, and the liver. Abdominal fat, VF, and vBMD of the lumbar spine were measured by QCT. For VF discrimination analysis, we examined both the whole cohort (60 VF cases in 30 men and 30 women) and a restricted subgroup of those aged over 50 years (50 VF cases in 23 men and 27 women). Results Amongst the men, a 1 SD increase in BMF was associated with a 27.67 (95% CI, -32.71 to -22.62) mg/cm(3) decrease in vBMD after adjusting for age and BMI. Amongst women, all adiposity indexes except for liver fat were significantly associated with vBMD, with BMF having the strongest association (beta, -24.00; 95% CI, -28.54 to -19.46 mg/cm(3)). Similar findings were also observed in participants aged over 50 years. The associations of adiposity indexes with vertebral fracture were not significant after adjusting for age in both sexes aged over 50 years. Conclusions In both sexes, higher bone marrow fat was associated with lower vBMD at the spine. However, marrow fat and other adipose tissues were not associated with radiographic-based prevalent vertebral fractures.
引用
收藏
页码:578 / 586
页数:9
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