Shifting our perspective on orphan G protein-coupled receptors

被引：1

作者：

Smith, Nicola J. ^{[1
]}

Murray, Fiona ^{[2
]}

机构：

[1] UNSW Sydney, Sch Biomed Sci, Dept Pharmacol, Sydney, NSW, Australia

[2] Univ Aberdeen, Inst Med Sci, Aberdeen, Scotland

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2024年 / 31卷 / 04期

基金：

英国惠康基金;

关键词：

INTERNATIONAL UNION; PHARMACOLOGY;

D O I：

10.1038/s41594-024-01270-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

G protein-coupled receptors (GPCRs) with no known endogenous ligand are termed orphans. Deorphanization of a GPCR involves identifying the ligand, which can be a painstaking exercise. In this Comment, we discuss the challenges in the process, its role in drug discovery and alternative approaches to characterizing orphan GPCRs.

引用

页码：582 / 583

页数：2

共 50 条

[21] A cellular perspective of bias at G protein-coupled receptors
Fernandez, Thomas J.
De Maria, Monica
Lobingier, Braden T.
PROTEIN SCIENCE, 2020, 29 (06) : 1345 - 1354
[22] Perspective on G protein-coupled receptors in renal physiology
Pluznick, Jennifer L.
Fenton, Robert A.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023, 325 (06) : F683 - F684
[23] A Latin American Perspective on G Protein-Coupled Receptors
Pupo, Andre S.
Adolfo Garcia-Sainz, J.
MOLECULAR PHARMACOLOGY, 2016, 90 (05) : 570 - 572
[24] The role of orphan G protein-coupled receptors in the pathophysiology of multiple sclerosis: A review
Alavi, Mohaddeseh Sadat
Karimi, Gholamreza
Roohbakhsh, Ali
LIFE SCIENCES, 2019, 224 : 33 - 40
[25] Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery
Stadel, JM
Wilson, S
Bergsma, DJ
TRENDS IN PHARMACOLOGICAL SCIENCES, 1997, 18 (11) : 430 - 437
[26] A new family of orphan G protein-coupled receptors predominantly expressed in the brain
Valdenaire, O
Giller, T
Breu, V
Ardati, A
Schweizer, A
Richards, JG
FEBS LETTERS, 1998, 424 (03) : 193 - 196
[27] G Protein-Coupled Receptors
Hoelz, Lucas V. B.
de Freitas, Guilherme B. L.
Torres, Pedro Henrique M.
Fernandes, Tacio Vinicio A.
Albuquerque, Magaly G.
da Silva, Joaquim Fernando M.
Pascutti, Pedro G.
de Alencastro, Ricardo B.
REVISTA VIRTUAL DE QUIMICA, 2013, 5 (05) : 981 - 1000
[28] Identification of signal transduction pathways used by orphan G protein-coupled receptors
Bresnick, JN
Skynner, HA
Chapman, KL
Jack, AD
Zamiara, E
Negulescu, P
Beaumont, K
Patel, S
McAllister, G
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2003, 1 (02) : 239 - 249
[29] Allosteric modulation of G protein-coupled receptors: A pharmacological perspective
Keov, Peter
Sexton, Patrick M.
Christopoulos, Arthur
NEUROPHARMACOLOGY, 2011, 60 (01) : 24 - 35
[30] Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets
Xiao-long Tang
Ying Wang
Da-li Li
Jian Luo
Ming-yao Liu
Acta Pharmacologica Sinica, 2012, 33 : 363 - 371

← 1 2 3 4 5 →