Shifting our perspective on orphan G protein-coupled receptors

被引：3

作者：

Smith, Nicola J. ^{[1
]}

Murray, Fiona ^{[2
]}

机构：

[1] UNSW Sydney, Sch Biomed Sci, Dept Pharmacol, Sydney, NSW, Australia

[2] Univ Aberdeen, Inst Med Sci, Aberdeen, Scotland

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2024年 / 31卷 / 04期

基金：

英国惠康基金;

关键词：

INTERNATIONAL UNION; PHARMACOLOGY;

D O I：

10.1038/s41594-024-01270-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

G protein-coupled receptors (GPCRs) with no known endogenous ligand are termed orphans. Deorphanization of a GPCR involves identifying the ligand, which can be a painstaking exercise. In this Comment, we discuss the challenges in the process, its role in drug discovery and alternative approaches to characterizing orphan GPCRs.

引用

页码：582 / 583

页数：2

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