Molecular profile in endometrial carcinoma: can we predict the lymph node status? A systematic review and meta-analysis

被引：5

作者：

Aznar, Ana Luzarraga ^{[1
,2
]}

Bebia, Vicente ^{[1
,2
]}

Gomez-Hidalgo, Natalia Rodriguez ^{[1
]}

Lopez-Gil, Carlos ^{[2
]}

Miguez, Marta ^{[1
]}

Colas, Eva ^{[2
]}

Perez-Benavente, Asuncion ^{[1
,2
]}

Gil-Moreno, Antonio ^{[1
,2
]}

Cabrera, Silvia ^{[1
,2
]}

机构：

[1] Hosp Univ Vall Hebron, Vall Hebron Barcelona Hosp Campus, Unitat Ginecol Oncol, Serv Ginecol, Barcelona, Spain

[2] Vall Hebron Barcelona Hosp Campus, Vall Hebron Inst Recerca VHIR, Grp Rec Biomed Ginecol, Barcelona, Spain

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2024年 / 26卷 / 07期

关键词：

Endometrial cancer; Molecular classification; Lymph node involvement; PARADIGM SHIFT; CANCER; GRADE; RISK; CLASSIFICATION; CONCORDANCE; PROMISE; REPRODUCIBILITY; BIOPSY;

D O I：

10.1007/s12094-024-03401-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PurposeMolecular classification of endometrial cancer (EC) has become a promising information to tailor preoperatively the surgical treatment. We aimed to evaluate the rate of lymph node metastases (LNM) in patients with EC according to molecular profile.MethodsA systematic review and meta-analysis were performed according to PRISMA guidelines by searching in two major electronic databases (PubMed and Scopus), including original articles reporting lymph node metastases according to the molecular classification of EC as categorized in the ESGO-ESMO-ESP guidelines.ResultsFifteen studies enrolling 3056 patients were included. Pooled prevalence LNM when considering only patients undergoing lymph node assessment was 4% for POLE-mutated (95%CI: 0-12%), 22% for no specific molecular profile (95% CI: 9-39%), 23% for Mismatch repair-deficiency (95%CI: 10-40%) and 31% for p53-abnormal (95%CI: 24-39%).ConclusionsThe presence of LNM seems to be influenced by molecular classification. P53-abnormal group presents the highest rate of nodal involvement, and POLE-mutated the lowest.

引用

页码：1768 / 1778

页数：11

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