Development of 3D-Printed Magnetic Micro-Nanorobots for Targeted Therapeutics: the State of Art

被引：8
作者：
Hu, Ningning [1 ,2 ]
Ding, Lujia [3 ]
Liu, Yuyi [3 ]
Wang, Kemin [1 ]
Zhang, Bing [1 ]
Yin, Ruixue [4 ]
Zhou, Wenju [1 ]
Bi, Zhuming [5 ]
Zhang, Wenjun [2 ]
机构：
[1] Shanghai Univ, Sch Mechatron Engn & Automat, Intelligent Energy Based Tumor Ablat Lab, Shanghai 200444, Peoples R China
[2] Univ Saskatchewan, Dept Mech Engn, Saskatoon, SK S7N 5A9, Canada
[3] Univ Saskatchewan, Div Biomed Engn, Saskatoon, SK S7N 5A9, Canada
[4] East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200237, Peoples R China
[5] Purdue Univ Ft Wayne, Dept Civil & Mech Engn, Ft Wayne, IN 46805 USA
来源：
ADVANCED NANOBIOMED RESEARCH | 2023年 / 3卷 / 10期
关键词：
biocompatibility; biodegradable materials; design and actuation; literature survey; magnetic; micro-/nanorobots; targeted therapeutic; ARTIFICIAL BACTERIAL FLAGELLA; 3D PRINTING TECHNOLOGY; 2-PHOTON POLYMERIZATION; MECHANICAL-PROPERTIES; AUTONOMOUS MOVEMENT; ACOUSTIC BUBBLE; DRUG-DELIVERY; MICROROBOTS; FABRICATION; STEREOLITHOGRAPHY;
D O I：
10.1002/anbr.202300018
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Micro-/nanorobots (mn-robots), inspired by the versatile mechanisms found in natural microorganisms, show great potential in enabling innovative bio-applications. The 3D-printed magnetic mn-robots are substantially advanced to swim in vivo and to carry and release therapeutic agents in a controlled manner. To understand the state of the art of such robots and identify their development trend, this article presents a comprehensive and systematic review of the recent works on development of magnetic robots and their applications in biomedical engineering, with a particular focus on targeted therapeutic delivery. The developments in materials, fabrications, actuations, and applications with design for magnetic mn-robots are reviewed, and it is aimed to discover the limitations of the existing works and to identify the knowledge gap, thereby deriving future research directions on developing magnetic mn-robots, especially for their applications in targeted therapeutic delivery. Micro-/nanorobots show great potential in enabling innovative bio-applications. The developments in magnetic micro-/nanorobots regarding their materials, fabrications, actuations, and applications are discussed in this article. Herein, it is aimed to discover the limitations of the existing works and to identify the knowledge gap, thereby deriving future directions on magnetic micro-/nanorobots, especially for their applications in targeted therapeutic delivery.image & COPY; 2023 WILEY-VCH GmbH
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页数：32
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