Integrated chemical safety assessment of food contact articles

Risk assessment of Non-Intentionally Added Substances (NIAS) present in food contact packaging that may migrate into food is a major challenge for food packagers and manufacturers and for risk assessors and managers. A strategy, consisting of combining analy-tical tools, in silico and in vitro studies, allowing the identification of the hazard in a complex mixture (packaging extract/migrate), is presented in this article. The aim is to avoid the pre-sence of undesirable, chemically uncharacterised or unknown substances in food. This approach appears all the more essential and relevant in a circular economy context, where the share of bio-based, reusable and recycled materials will increase considerably in the coming years. To date, traceability of these new materials is, for the most part, difficult.(c) 2022 Societe francaise de nutrition. Published by Elsevier Masson SAS. All rights reserved.