The expanding roles of PI4P and PI(4,5)P2 at the plasma membrane: Role of phosphatidylinositol transfer proteins

被引：4

作者：

Cockcroft, Shamshad ^{[1
]}

机构：

[1] UCL, Dept Neurosci Physiol & Pharmacol, Div Biosci, 21 Univ St, London WC1E 6JJ, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2024年 / 1869卷 / 02期

关键词：

Phospholipase C; Phosphatidylinositol; Phosphatidylinositol transfer proteins; RdgB; RETINAL-DEGENERATION-B; PM CONTACT SITES; LIPID TRANSFER; RDGB-ALPHA; BETA; GOLGI; NIR2; ER; PURIFICATION; HOMEOSTASIS;

D O I：

10.1016/j.bbalip.2023.159394

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphoinositides are phosphorylated derivatives of phosphatidylinositol, a phospholipid that is synthesised at the endoplasmic reticulum. The plasma membrane contains the enzymes to phosphorylate phosphatidylinositol and is therefore rich in the phosphorylated derivatives, PI4P and PI(4,5)P2. PI(4,5)P2 is a substrate for phospholipase C and during cell signaling, PI(4,5)P2 levels are reduced. Here I discuss a family of proteins, phosphatidylinositol transfer proteins (PITPs) that can restore PI(4,5)P2 levels.

引用

页数：4

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