Atelocollagen-associated autologous chondrocyte implantation for the repair of large cartilage defects of the knee: Results at three to seven years

被引：4

作者：

Kaibara, Takuma ^{[1
]}

Kondo, Eiji ^{[2
]}

Matsuoka, Masatake ^{[1
]}

Iwasaki, Koji ^{[3
]}

Onodera, Tomohiro ^{[1
]}

Sakamoto, Keita ^{[4
]}

Oda, Yoshitaka ^{[5
]}

Tanei, Zen-ichi ^{[5
]}

Momma, Daisuke ^{[2
]}

Tanaka, Shinya ^{[5
]}

Iwasaki, Norimasa ^{[1
]}

机构：

[1] Hokkaido Univ, Dept Orthopaed Surg, Grad Sch Med, Kita 15,Nish 7,Kita Ku, Sapporo, Hokkaido 0608638, Japan

[2] Hokkaido Univ Hosp, Ctr Sports Med, Kita 14,Nishi 5,Kita Ku, Sapporo 0608648, Japan

[3] Hokkaido Univ, Dept Funct Reconstruct Knee Joint, Kita 15,Nish 7,Kita Ku, Sapporo, Hokkaido 0608638, Japan

[4] Hokkaido Univ Hosp, Dept Diagnost & Intervent Radiol, Kita 14,Nish 5,Kita Ku, Sapporo, Hokkaido 0608648, Japan

[5] Hokkaido Univ, Fac Med, Dept Canc Pathol, Kita 15,Nish 7,Kita Ku, Sapporo, Japan

来源：

JOURNAL OF ORTHOPAEDIC SCIENCE | 2024年 / 29卷 / 01期

关键词：

Atelocollagen; Autologous chondrocyte implantation; Large cartilage defect; Knee; LONG-TERM OUTCOMES; ARTICULAR-CARTILAGE; GRAFT HYPERTROPHY; CHONDRAL DEFECTS; CLINICAL-TRIAL; FOLLOW-UP; TISSUE; TRANSPLANTATION; MINIMUM; QUALITY;

D O I：

10.1016/j.jos.2022.12.001

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Background: Recently, various types of engineered autologous chondrocyte implantation (ACI) have been developed. Atelocollagen-associated ACI (A-ACI) is the only ACI procedure covered by Japanese Health Insurance since 2013. The indications of the A-ACI are traumatic cartilage defects and osteochondral dissecans (OCD) for knee joints. Purpose: To evaluate midterm clinical results after A-ACI for the treatment for full-thickness cartilage defects of the knee. Methods: Thirteen consecutive patients who underwent A-ACI between 2014 and 2018 had been prospectively enrolled in this study. There were 11 men and 2 women with a mean age of 34 years at the time of surgery. The causes of the cartilage defect were trauma in 10 knees and OCD in 3 knees. The total number of lesions was 15, which were comprised of the medial femoral condyle in 5 knees, the lateral femoral condyle in 5 knees, and the femoral trochlea in 5 knees. The mean size of the lesion was 5.3 cm(2). Each knee was clinically and radiologically evaluated preoperatively and postoperatively. Results: The mean Lysholm score improved significantly from 74.0 points to 94.0 points (p = 0.008) and each subscale in Knee injury and Osteoarthritis Outcome Score improved significantly (p < 0.001) at the mean final follow-up period of 51 months (range, 36-84 months). The magnetic resonance observation of cartilage repair tissue 2.0 score at the mean follow-up of 38 months was significantly higher than that at 2 months postoperatively (p = 0.014). According to the International Cartilage Repair Society (ICRS) grading scale, 3 knees were graded as normal, 3 knees as nearly normal, and 1 knee as severely abnormal in second-look arthroscopic evaluation at a mean of 22 months (range, 8-41 months) after A-ACI. Conclusion: The present study showed a significant subjective and objective clinical improvement in the A-ACI for large cartilage defects of the knee at a mean follow-up of 51 months (range, 36-84 months). (c) 2022 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.

引用

页码：207 / 216

页数：10

共 34 条

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