A screening method for cervical myelopathy using machine learning to analyze a drawing behavior

被引:4
作者
Yamada, Eriku [1 ]
Fujita, Koji [2 ]
Watanabe, Takuro [3 ]
Koyama, Takafumi [1 ]
Ibara, Takuya [2 ]
Yamamoto, Akiko [1 ]
Tsukamoto, Kazuya [1 ]
Kaburagi, Hidetoshi [1 ]
Nimura, Akimoto [2 ]
Yoshii, Toshitaka [1 ]
Sugiura, Yuta [3 ]
Okawa, Atsushi [1 ]
机构
[1] Tokyo Med & Dent Univ TMDU, Grad Sch Med & Dent Sci, Dept Orthoped & Spinal Surg, 1-5-45 Yushima,Bunkyo Ku, Tokyo 1138519, Japan
[2] Tokyo Med & Dent Univ TMDU, Grad Sch Med & Dent Sci, Dept Funct Joint Anat, 1-5-45 Yushima,Bunkyo Ku, Tokyo 1138519, Japan
[3] Keio Univ, Sch Sci Open & Environm Syst, Grad Sch Sci & Technol, 3-14-1 Hiyoshi,Kohoku Ku, Yokohama, Kanagawa 2238522, Japan
关键词
SPONDYLOTIC MYELOPATHY; DIAGNOSIS; COORDINATION; RELIABILITY; OUTCOMES;
D O I
10.1038/s41598-023-37253-3
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Early detection of cervical myelopathy (CM) is important for a favorable outcome, as its prognosis is poor when left untreated. We developed a screening method for CM using machine learning-based analysis of the drawing behavior of 38 patients with CM and 66 healthy volunteers. Using a stylus pen, the participants traced three different shapes displayed on a tablet device. During the tasks, writing behaviors, such as the coordinates, velocity, and pressure of the stylus tip, along with the drawing time, were recorded. From these data, features related to the drawing pressure, and time to trace each shape and combination of shapes were used as training data for the support vector machine, a machine learning algorithm. To evaluate the accuracy, a receiver operating characteristic curve was generated, and the area under the curve (AUC) was calculated. Models with triangular waveforms tended to be the most accurate. The best triangular wave model identified patients with and without CM with 76% sensitivity and 76% specificity, yielding an AUC of 0.80. Our model was able to classify CM with high accuracy and could be applied to the development of disease screening systems useful outside the hospital setting.
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页数:8
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共 40 条
[1]   Automated human-level diagnosis of dysgraphia using a consumer tablet [J].
Asselborn, Thibault ;
Gargot, Thomas ;
Kidzinski, Lukasz ;
Johal, Wafa ;
Cohen, David ;
Jolly, Caroline ;
Dillenbourg, Pierre .
NPJ DIGITAL MEDICINE, 2018, 1
[2]   On the analysis of movement smoothness [J].
Balasubramanian, Sivakumar ;
Melendez-Calderon, Alejandro ;
Roby-Brami, Agnes ;
Burdet, Etienne .
JOURNAL OF NEUROENGINEERING AND REHABILITATION, 2015, 12
[3]   Efficient leave-one-out cross-validation of kernel Fisher discriminant classifiers [J].
Cawley, GC ;
Talbot, NLC .
PATTERN RECOGNITION, 2003, 36 (11) :2585-2592
[4]   Cervical spondylotic myelopathy: Patterns of neurological deficit and recovery after anterior cervical decompression [J].
Chiles, BW ;
Leonard, MA ;
Choudhri, HF ;
Cooper, PR .
NEUROSURGERY, 1999, 44 (04) :762-769
[5]   Clustered clinical findings for diagnosis of cervical spine myelopathy [J].
Cook, Chad ;
Brown, Christopher ;
Isaacs, Robert ;
Roman, Matthew ;
Davis, Samuel ;
Richardson, William .
JOURNAL OF MANUAL & MANIPULATIVE THERAPY, 2010, 18 (04) :175-180
[6]   Reliability and Diagnostic Accuracy of Clinical Special Tests for Myelopathy in Patients Seen for Cervical Dysfunction [J].
Cook, Chad ;
Roman, Matthew ;
Stewart, Kathleen M. ;
Leithe, Linda Gray ;
Isaacs, Robert .
JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY, 2009, 39 (03) :172-178
[7]   CERVICAL SPONDYLOTIC MYELOPATHY [J].
CRANDALL, PH ;
BATZDORF, U .
JOURNAL OF NEUROSURGERY, 1966, 25 (01) :57-+
[8]   Coordination dynamics of elliptic shape drawing: Effects of orientation and eccentricity [J].
Danna, Jeremy ;
Athenes, Sylvie ;
Zanone, Pier-Giorgio .
HUMAN MOVEMENT SCIENCE, 2011, 30 (04) :698-710
[9]   A Novel Insight Into the Challenges of Diagnosing Degenerative Cervical Myelopathy Using Web-Based Symptom Checkers [J].
Davies, Benjamin Marshall ;
Munro, Colin Fraser ;
Kotter, Mark R. N. .
JOURNAL OF MEDICAL INTERNET RESEARCH, 2019, 21 (01)
[10]   Interjoint coordination during handwriting-like movements [J].
Dounskaia, N ;
Van Gemmert, AWA ;
Stelmach, GE .
EXPERIMENTAL BRAIN RESEARCH, 2000, 135 (01) :127-140