Ultrashort Peptides for the Self-Assembly of an Antiviral Coating

被引：8

作者：

Hu, Tan ^{[1
,2
,3
,4
]}

Kaganovich, Michaela ^{[1
,2
]}

Shpilt, Zohar ^{[1
,2
]}

Pramanik, Apurba ^{[1
,2
]}

Agazani, Omer ^{[1
,2
]}

Pan, Siyi ^{[3
,4
]}

Tshuva, Edit ^{[1
,2
]}

Reches, Meital ^{[1
,2
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, IL-91904 Jerusalem, Israel

[3] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Hubei, Peoples R China

[4] Huazhong Agr Univ, Key Lab Environm Correlat Dietol, Minist Educ, Wuhan 430070, Hubei, Peoples R China

来源：

ADVANCED MATERIALS INTERFACES | 2023年 / 10卷 / 06期

关键词：

antiviral; bacteriophage T4; nanoparticles; peptides; self-assembly; INFLUENZA-VIRUS; INACTIVATION; PROTEIN; FLUORINE;

D O I：

10.1002/admi.202202161

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Antiviral compounds are important for generating sterile surfaces. Here, two extremely short peptides, DOPA-Phe-NH2 and DOPA-Phe(4F)-NH2 that can self-assemble into spherical nanoparticles with antiviral activity are presented. The peptide assemblies possess excellent antiviral activity against bacteriophage T4 with antiviral minimal inhibitory concentrations of 125 and 62.5 mu g mL(-1), for DOPA-Phe-NH2 and DOPA-Phe(4F)-NH2, respectively. When the peptide assemblies are applied on a glass substrate by drop-casting, they deactivate more than 99.9% of bacteriophage T4 and Canine coronavirus. Importantly, the peptide assemblies have low toxicity toward mammalian cells. Overall, the findings can provide a novel strategy for the design and development of antiviral coatings for a decreased risk of viral infections.

引用

页数：8