Effect of remdesivir on mortality rate and clinical status of COVID-19 patients: a systematic review with meta-analysis

被引：7
|
作者：
Sellitto, Carmine [1 ]
Corbi, Graziamaria [2 ,7 ]
Bertini, Nicola [1 ]
Ascione, Tiziana [3 ]
Costantino, Maria [1 ,4 ]
Scarpati, Giuliana [5 ]
Piazza, Ornella [5 ]
Filippelli, Amelia [1 ]
Conti, Valeria [1 ]
Pagliano, Pasquale [6 ]
机构：
[1] Univ Salerno, Dept Med Surg & Dent, Unit Pharmacol, Scuola Med Salernitana, Baronissi, Italy
[2] Univ Molise, Dept Med & Hlth Sci V Tiberio, Campobasso, Italy
[3] Cardarelli Hosp, Dept Med, Serv Infect Dis, Naples, Italy
[4] Assoc Nonprofit FIRS Thermae Interdisciplinary Tr, Naples, Italy
[5] Univ Salerno, Dept Med Surg & Dent, Unit Anesthesiol, Scuola Med Salernitana, Baronissi, Italy
[6] Univ Salerno, Dept Med Surg & Dent, Unit Infect Dis, Scuola Med Salernitana, Baronissi, Italy
[7] Univ Naples Federico II, Dept Translat Med Sci, Naples, Italy
来源：
JOURNAL OF CHEMOTHERAPY | 2023年 / 35卷 / 05期
关键词：
Remdesivir; COVID-19; mortality; oxygen support; length of stay; time to clinical improvement; DISEASE; 2019; COVID-19; CORONAVIRUS;
D O I：
10.1080/1120009X.2022.2121091
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Remdesivir (RDV) is a broad-spectrum antiviral drug, now approved by Regulatory Agencies for COVID-19 treatment. RDV is associated with improvements in clinical outcomes, but no conclusive studies have shown an effect in reducing mortality. This study aimed to carry out a systematic review with meta-analysis to investigate whether RDV can significantly modify the outcome of COVID-19 patients evaluating its effects on mortality, length of stay, time to clinical improvement and need for oxygen supplementation. No significant improvement in terms of survival in patients treated with standard therapy (ST)+RDV as compared to ST alone (P = 0.24) was found. The duration of oxygen support was significantly lower in patients treated with ST + RDV compared with ST alone (P = 0.03). Further investigations should be planned to assess the real impact of RDV in the management of COVID-19 patients.
引用
收藏
页码：383 / 396
页数：14
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