Health impacts of endotoxin-particulate matter inhalation, effects beyond cardiopulmonary toxicity

被引:1
作者
Baldriche-Acosta, Jessica [1 ]
De Vizcaya-Ruiz, Andrea [2 ]
Barbier, Olivier Christophe [1 ]
Aztatzi-Aguilar, Octavio Gamaliel [1 ]
机构
[1] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Toxicol, Mexico City, Mexico
[2] Univ Calif Irvine, Dept Environm & Occupat Hlth, Irvine, CA USA
关键词
Endotoxin; PM2.5; inhalation exposure; extrapulmonary effects; health effects; AIRBORNE ENDOTOXIN; IN-VITRO; INFLAMMATORY RESPONSE; INHALED ENDOTOXIN; AMBIENT PARTICLES; MATERNAL EXPOSURE; AIR-POLLUTION; CELL-DEATH; LIPOPOLYSACCHARIDE; PM2.5;
D O I
10.1080/15569543.2024.2317291
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Exposure to high levels of particulate matter <2.5 mu m (PM2.5) causes cardiorespiratory diseases due to oxidative stress and inflammation. The toxicity of PM2.5 depends on particle size and composition. PM2.5 can reach organs far from the lungs, such as the brain, heart, kidneys, and adipose tissue, affecting their function. Moreover, endotoxin, an important component of PM2.5, has recently been suggested as a risk factor for the development of metabolic, autoimmune, neurodegenerative, and renal diseases. Most published studies focus only on cardiorespiratory symptoms, airway inflammation, and impaired lung function. An amplified inflammation of the airways can transcend to other organs and cause genetic, biochemical, tissue, and physiological alterations. This review focuses on the role of endotoxin as an air pollutant, its adverse health effects, and the discussion on whether it should be considered as an air quality parameter.
引用
收藏
页码:211 / 223
页数:13
相关论文
共 111 条
  • [1] Inflammatory cytokines in the pathogenesis of cardiovascular disease and cancer
    Amin, Mohammad Nurul
    Siddiqui, Shafayet Ahmed
    Ibrahim, Md
    Hakim, Md Lukman
    Ahammed, Md. Salim
    Kabir, Asma
    Sultana, Farhana
    [J]. SAGE OPEN MEDICINE, 2020, 8
  • [2] Early kidney damage induced by subchronic exposure to PM2.5 in rats
    Aztatzi-Aguilar, O. G.
    Uribe-Ramirez, M.
    Narvaez-Morales, J.
    De Vizcaya-Ruiz, A.
    Barbier, O.
    [J]. PARTICLE AND FIBRE TOXICOLOGY, 2016, 13
  • [3] The gut microbiota as an environmental factor that regulates fat storage
    Bäckhed, F
    Ding, H
    Wang, T
    Hooper, LV
    Koh, GY
    Nagy, A
    Semenkovich, CF
    Gordon, JI
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) : 15718 - 15723
  • [4] BANG FB, 1956, B JOHNS HOPKINS HOSP, V98, P325
  • [5] Predictors of coarse particulate matter and associated endotoxin concentrations in residential environments
    Bari, Md. Aynul
    MacNeill, Morgan
    Kindzierski, Warren B.
    Wallace, Lance
    Heroux, Marie-Eve
    Wheeler, Amanda J.
    [J]. ATMOSPHERIC ENVIRONMENT, 2014, 92 : 221 - 230
  • [6] Short-term dynamics of indoor and outdoor endotoxin exposure: Case of Santiago, Chile, 2012
    Barraza, Francisco
    Jorquera, Hector
    Heyer, Johanna
    Palma, Wilfredo
    Maria Edwards, Ana
    Munoz, Marcelo
    Valdivia, Gonzalo
    Montoya, Lupita D.
    [J]. ENVIRONMENT INTERNATIONAL, 2016, 92-93 : 97 - 105
  • [7] Behrman RE, 2007, Preterm Birth: Causes, Consequences, and Prevention, DOI DOI 10.17226/11622
  • [8] NADPH Oxidases in Lung Health and Disease
    Bernard, Karen
    Hecker, Louise
    Luckhardt, Tracy R.
    Cheng, Guangjie
    Thannickal, Victor J.
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2014, 20 (17) : 2838 - 2853
  • [9] Endotoxin recovery using limulus amebocyte lysate (LAL) assay
    Bolden, Jay S.
    Warburton, Rob E.
    Phelan, Robert
    Murphy, Marie
    Smith, Kelly R.
    De Felippis, Michael R.
    Chen, Dayue
    [J]. BIOLOGICALS, 2016, 44 (05) : 434 - 440
  • [10] Induction of the lung myofibroblast PDGF receptor system by urban ambient particles from Mexico City
    Bonner, JC
    Rice, AB
    Lindroos, PM
    O'Brien, PO
    Dreher, KL
    Rosas, I
    Alfaro-Moreno, E
    Osornio-Vargas, AR
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1998, 19 (04) : 672 - 680