Conveying the pathogenesis of type 1 diabetes to the blind, low-vision and diverse needs communities through sensory stimulation

被引:1
作者
Tran, Mai T. [1 ,2 ]
Ciacchi, Laura [1 ,2 ]
Ciacchi, Lisa [1 ,2 ]
Reid, Hugh H. [1 ,2 ]
机构
[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic, Australia
[2] Monash Univ, Biomed Discovery Inst, Immun Program, Clayton, Vic, Australia
关键词
autoimmune diseases; disability inclusion in Science; MHC; science education; T cells; type; 1; diabetes; T-CELLS;
D O I
10.1111/imcb.12741
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
To educate members of the blind, low-vision and diverse needs communities on the pathogenesis of the chronic autoimmune disease, type 1 diabetes, members of our team with research expertise in immune-mediated diseases, participated in the 2023 Monash Sensory Science (MSS) Exhibition. Using QR code linked audio commentary, participants were guided through tactile displays demonstrating normal insulin action in the regulation of blood glucose levels and its vital role in providing energy to tissues, followed by displays describing the various stages of the immune system's aberrant attack and the eventual complete destruction of the insulin producing beta-cells of the pancreatic islets in type 1 diabetes. These models conveyed to the participants the huge effect that this autoimmune-mediated disease has on the quality of life of affected individuals including the subsequent lifelong reliance on insulin injections to maintain glucose homeostasis. This MSS Exhibition provided a unique opportunity for our researchers to engage with under-represented members of the community and to raise awareness about such a debilitating and common autoimmune disease.
引用
收藏
页码:341 / 346
页数:6
相关论文
共 9 条
[1]  
[Anonymous], 2022, TYPE 1 DIABETES INDE
[2]   Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion [J].
Delong, Thomas ;
Wiles, Timothy A. ;
Baker, Rocky L. ;
Bradley, Brenda ;
Barbour, Gene ;
Reisdorph, Richard ;
Armstrong, Michael ;
Powell, Roger L. ;
Reisdorph, Nichole ;
Kumar, Nitesh ;
Elso, Colleen M. ;
DeNicola, Megan ;
Bottino, Rita ;
Powers, Alvin C. ;
Harlan, David M. ;
Kent, Sally C. ;
Mannering, Stuart I. ;
Haskins, Kathryn .
SCIENCE, 2016, 351 (6274) :711-714
[3]   Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study br [J].
Gregory, Gabriel A. ;
Robinson, Thomas I. G. ;
Linklater, Sarah E. ;
Wang, Fei ;
Colagiuri, Stephen ;
de Beaufort, Carine ;
Donaghue, Kim C. ;
Magliano, Dianna J. ;
Maniam, Jayanthi ;
Orchard, Trevor J. ;
Rai, Priyanka ;
Ogle, Graham D. .
LANCET DIABETES & ENDOCRINOLOGY, 2022, 10 (10) :741-760
[4]  
Han SH, 2013, AM J TRANSL RES, V5, P379
[5]  
JDRF, AUSTR LIVING DIABETE
[6]   Immunogenetics of type 1 diabetes: A comprehensive review [J].
Noble, Janelle A. .
JOURNAL OF AUTOIMMUNITY, 2015, 64 :101-112
[7]  
Ogle GD, 2023, CURR DIABETES REP, V23, P277, DOI 10.1007/s11892-023-01520-4
[8]   Autoreactive T cells in type 1 diabetes [J].
Pugliese, Alberto .
JOURNAL OF CLINICAL INVESTIGATION, 2017, 127 (08) :2881-2891
[9]   T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8 [J].
Tran, Mai T. ;
Faridi, Pouya ;
Lim, Jia Jia ;
Ting, Yi Tian ;
Onwukwe, Goodluck ;
Bhattacharjee, Pushpak ;
Jones, Claerwen M. ;
Tresoldi, Eleonora ;
Cameron, Fergus J. ;
La Gruta, Nicole L. ;
Purcell, Anthony W. ;
Mannering, Stuart, I ;
Rossjohn, Jamie ;
Reid, Hugh H. .
NATURE COMMUNICATIONS, 2021, 12 (01)