Volumetric Remodeling of the Left Liver After Right Hepatectomy: Analysis of Factors Predicting Degree of Hypertrophy and Post-hepatectomy Liver Failure

被引:0
|
作者
de Mathelin, Pierre [1 ,2 ]
Noblet, Vincent [2 ]
Trog, Arnaud [2 ]
Paul, Chloe [1 ]
Cusumano, Caterina [1 ]
Faitot, Francois [1 ,2 ]
Bachellier, Philippe [1 ]
Addeo, Pietro [1 ,2 ]
机构
[1] Univ Strasbourg, Hop Hautepierre, Hop Univ Strasbourg, Hepatopancreato Biliary Surg & Liver Transplantat,, France 1,Ave Moliere, F-67098 Strasbourg, France
[2] Univ Strasbourg, ICube, CNRS UMR 7357, Illkirch Graffenstaden, France
关键词
Degree of hypertrophy; Kinetic growth rate; Liver volume; Post-hepatectomy liver failure; Right hepatectomy; Standardized future liver remnant; Anthropometrics; Gender; Middle hepatic vein; Regeneration; Remodeling; PORTAL-VEIN EMBOLIZATION; KINETIC GROWTH-RATE; REMNANT LIVER; HEPATIC RESECTION; LIVING DONORS; REGENERATION; MORTALITY; METASTASIS; MORBIDITY; OUTCOMES;
D O I
10.1007/s11605-023-05804-8
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background This study investigated the volumetric remodeling of the left liver after right hepatectomy looking for factors predicting the degree of hypertrophy and severe post-hepatectomy liver failure (PHLF).Methods In a cohort of 121 right hepatectomies, we performed CT volumetrics study of the future left liver remnant (FLR) preoperatively and postoperatively. Factors influencing FLR degree of hypertrophy and severe PHLF were identified by multivariate analysis.Results After right hepatectomy, the mean degree of hypertrophy and kinetic growth rate of the left liver remnant were 25% and 3%/day respectively. The mean liver volume recovery rate was 77%. Liver remodeling volume was distributed for 79% on segments 2 and 3 and 21% on the segment 4 (p<0.001). Women showed a greater hypertrophy of segments 2 and 3 compared with men (p=0.002). The degree of hypertrophy of segment 4 was lower in case of middle hepatic vein resection (p=0.004). Left liver remnant kinetic growth rate was associated with the standardized future liver remnant (sFLR) (p<0.001) and a two-stage hepatectomy (p=0.023). Severe PHLF were predicted by intraoperative transfusion (p=0.009), biliary tumors (p=0.013), and male gender (p=0.022).Conclusions Volumetric remodeling of the left liver after right hepatectomy is not uniform and is mainly influenced by gender and sacrifice of middle hepatic vein. Male gender, intraoperative transfusion, and biliary tumors increase the risk of postoperative liver failure after right hepatectomy.
引用
收藏
页码:2752 / 2762
页数:11
相关论文
共 50 条
  • [1] Volumetric Remodeling of the Left Liver After Right Hepatectomy: Analysis of Factors Predicting Degree of Hypertrophy and Post-hepatectomy Liver Failure
    Pierre de Mathelin
    Vincent Noblet
    Arnaud Trog
    Chloé Paul
    Caterina Cusumano
    François Faitot
    Philippe Bachellier
    Pietro Addeo
    Journal of Gastrointestinal Surgery, 2023, 27 : 2752 - 2762
  • [2] Predicting post-hepatectomy liver failure by combined volumetric, functional MR image and laboratory analysis
    Chuang, Yi-Hsuan
    Ou, Hsin-You
    Lazo, Marirose Z.
    Chen, Chao-Long
    Chen, Meng-Hsiang
    Weng, Ching-Chun
    Cheng, Yu-Fan
    LIVER INTERNATIONAL, 2018, 38 (05) : 868 - 874
  • [3] Risk factors for post-hepatectomy liver failure in 80 patients
    Xing, Ying
    Liu, Zheng-Rong
    Yu, Wei
    Zhang, Hong-Yi
    Song, Mao-Min
    WORLD JOURNAL OF CLINICAL CASES, 2021, 9 (08) : 1793 - 1802
  • [4] Risk factors for post-hepatectomy liver failure in 80 patients
    Ying Xing
    Zheng-Rong Liu
    Wei Yu
    Hong-Yi Zhang
    Mao-Min Song
    World Journal of Clinical Cases, 2021, 9 (08) : 1793 - 1802
  • [5] Salvage Plasmapheresis for Post-hepatectomy Liver Failure
    Inayat, Faisal
    Hussain, Qulsoom
    Tasleem, Syed H.
    Farooq, Sajid
    Hurairah, Abu
    CUREUS, 2016, 8 (11):
  • [6] New Paradigms in Post-hepatectomy Liver Failure
    Nicolas Golse
    Petru O. Bucur
    René Adam
    Denis Castaing
    Antonio Sa Cunha
    Eric Vibert
    Journal of Gastrointestinal Surgery, 2013, 17 : 593 - 605
  • [7] New Paradigms in Post-hepatectomy Liver Failure
    Golse, Nicolas
    Bucur, Petru O.
    Adam, Rene
    Castaing, Denis
    Cunha, Antonio Sa
    Vibert, Eric
    JOURNAL OF GASTROINTESTINAL SURGERY, 2013, 17 (03) : 593 - 605
  • [8] Post-hepatectomy liver failure in patients with colorectal liver metastases
    Masato Narita
    Elie Oussoultzoglou
    Philippe Bachellier
    Daniel Jaeck
    Shinji Uemoto
    Surgery Today, 2015, 45 : 1218 - 1226
  • [9] Post-hepatectomy liver failure in patients with colorectal liver metastases
    Narita, Masato
    Oussoultzoglou, Elie
    Bachellier, Philippe
    Jaeck, Daniel
    Uemoto, Shinji
    SURGERY TODAY, 2015, 45 (10) : 1218 - 1226
  • [10] Post-hepatectomy liver failure: A timeline centered review
    Bekheit, Mohamed
    Grundy, Lisa
    Salih, Ahmed K. A.
    Bucur, Petru
    Vibert, Eric
    Ghazanfar, Mudassar
    HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, 2023, 22 (06) : 554 - 569