Vitiligo: A Review of Aetiology, Pathogenesis, Treatment, and Psychosocial Impact

被引:22
作者
AL-smadi, Khadeejeh [1 ]
Imran, Mohammad [1 ]
Leite-Silva, Vania R. [1 ,2 ]
Mohammed, Yousuf [1 ,3 ]
机构
[1] Univ Queensland, Frazer Inst, Brisbane, Qld 4102, Australia
[2] Univ Fed Sao Paulo, UNIFESP, Dept Ciencias Farmaceut, Inst Ciencias Ambientais Quim & Farmaceut, BR-09913030 Diadema, Brazil
[3] Univ Queensland, Sch Pharm, Brisbane, Qld 4102, Australia
关键词
vitiligo; melanocyte; macule; patch; Fitzpatrick phototype; QUALITY-OF-LIFE; NONMELANOMA SKIN-CANCER; AUTOIMMUNE-DISEASES; TOPICAL CALCIPOTRIOL; DOUBLE-BLIND; SEGMENTAL VITILIGO; HIGH-FREQUENCY; A THERAPY; COMBINATION; PLACEBO;
D O I
10.3390/cosmetics10030084
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Vitiligo is an acquired, chronic condition characterised by depigmentation of the epidermis or by destruction/loss of melanin. Skin cells (melanocytes) are responsible for producing melanin, the substance that gives pigmentation to the skin. This review aims to provide a comprehensive overview of the current state of knowledge about vitiligo. Although there is no specific ethnic group, gender, or skin type that is more prone to vitiligo than others, it can affect anyone. The most commonly prescribed treatments for vitiligo are systemic and topical phototherapy and immunomodulators such as corticosteroids, calcineurin inhibitors, and vitamin D analogues, in addition to cosmetics that can camouflage and improve the quality of life. Even though vitiligo is typically thought of as a cosmetic disorder, its effects on the physical and psychosocial health of sufferers cannot be ignored.
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页数:14
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