Marine Organisms as a Prolific Source of Bioactive Depsipeptides

被引：20

作者：

Zeng, Mingyuan ^{[1
]}

Tao, Jianyun ^{[1
]}

Xu, Shuang ^{[1
]}

Bai, Xuelian ^{[2
]}

Zhang, Huawei ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Sch Pharmaceut Sci, Hangzhou 310014, Peoples R China

[2] Hangzhou Normal Univ, Coll Life & Environm Sci, Hangzhou 311121, Peoples R China

来源：

MARINE DRUGS | 2023年 / 21卷 / 02期

基金：

中国国家自然科学基金;

关键词：

depsipeptide; marine cyanobacterium; sponge; mollusk; marine microbe; alga; biological activity; NEW-GUINEA COLLECTION; CYTOTOXIC CYCLIC DEPSIPEPTIDE; POTENT ELASTASE INHIBITORS; A-C; CHYMOTRYPSIN INHIBITOR; PROTEASE INHIBITORS; LYNGBYA-MAJUSCULA; KAHALALIDE F; CYANOBACTERIUM; CYCLODEPSIPEPTIDE;

D O I：

10.3390/md21020120

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Depsipeptides, an important group of polypeptides containing residues of hydroxy acids and amino acids linked together by amide and ester bonds, have potential applications in agriculture and medicine. A growing body of evidence demonstrates that marine organisms are prolific sources of depsipeptides, such as marine cyanobacteria, sponges, mollusks, microorganisms and algae. However, these substances have not yet been comprehensively summarized. In order to enrich our knowledge about marine depsipeptides, their biological sources and structural features, as well as bioactivities, are highlighted in this review after an extensive literature search and data analysis.

引用

页数：21

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