Pericytes in the tumor microenvironment

被引：91

作者：

Jiang, Zhongyi ^{[1
,2
]}

Zhou, Jing ^{[1
,2
]}

Li, Luohong ^{[1
,2
]}

Liao, Shan ^{[3
]}

He, Junyu ^{[1
,2
]}

Zhou, Shubo ^{[4
]}

Zhou, Yanhong ^{[1
,2
]}

机构：

[1] Cent South Univ, Hunan Canc Hosp, NHC Key Lab Carcinogenesis, Affiliated Canc Hosp,Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China

[2] Cent South Univ, Canc Res Inst, Basic Sch Med, Changsha 410078, Hunan, Peoples R China

[3] Cent South Univ, Xiangya Hosp 3, Dept Pathol, Changsha 410013, Hunan, Peoples R China

[4] Yiyang Cent Hosp, Dept Neurosurg, 118 Kang Fu Rd, Yiyang 413000, Hunan, Peoples R China

来源：

CANCER LETTERS | 2023年 / 556卷

关键词：

Pericytes; Tumor microenvironment; Tumor -associated macrophages; Tumor therapy; Epithelial-mesenchymal transition; VASCULAR NORMALIZATION; HEPATOCELLULAR-CARCINOMA; VESSEL NORMALIZATION; PDGF-BB; ANTI-PD-1; THERAPY; CANCER; METASTASIS; INHIBITION; ANGIOGENESIS; GROWTH;

D O I：

10.1016/j.canlet.2023.216074

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pericytes are a type of mural cell located between the endothelial cells of capillaries and the basement membrane, which function to regulate the capillary vasomotor and maintain normal microcirculation of local tissues and organs and have been identified as a significant component in the tumor microenvironment (TME). Pericytes have various interactions with different components of the TME, such as constituting the pre-metastatic niche, promoting the growth of cancer cells and drug resistance through paracrine activity, and inducing M2 macrophage polarization. While changes in the TME can affect the number, phenotype, and molecular markers of pericytes. For example, pericyte detachment from endothelial cells in the TME facilitates tumor cells in situ to invade the circulating blood and is beneficial to local capillary basement membrane enzymatic hydrolysis and endothelial cell proliferation and budding, which contribute to tumor angiogenesis and metastasis. In this review, we discuss the emerging role of pericytes in the TME, and tumor treatment related to pericytes. This review aimed to provide a more comprehensive understanding of the function of pericytes and the relationship between pericytes and tumors and to provide ideas for the treatment and prevention of malignant tumors.

引用

页数：10

共 108 条

[1] Eribulin mesylate exerts specific gene expression changes in pericytes and shortens pericyte-driven capillary network in vitro [J].