Systemic treatments for breast cancer brain metastasis

被引：7

作者：

Chen, Qiuchi ^{[1
]}

Xiong, Jie ^{[1
]}

Ma, Yuxi ^{[1
]}

Wei, Jielin ^{[1
]}

Liu, Cuiwei ^{[1
]}

Zhao, Yanxia ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Canc Ctr, Wuhan, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 12卷

基金：

中国国家自然科学基金;

关键词：

breast cancer; brain metastasis; systemic treatment; targeted treatment; endocrine treatment; LAPATINIB PLUS CAPECITABINE; TRASTUZUMAB EMTANSINE T-DM1; CELL LUNG-CANCER; PHASE-II TRIAL; SACITUZUMAB GOVITECAN; RADIATION-THERAPY; SUBGROUP ANALYSIS; SINGLE-ARM; SURVIVAL; TEMOZOLOMIDE;

D O I：

10.3389/fonc.2022.1086821

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer (BC) is the most common cancer in females and BC brain metastasis (BCBM) is considered as the second most frequent brain metastasis. Although the advanced treatment has significantly prolonged the survival in BC patients, the prognosis of BCBM is still poor. The management of BCBM remains challenging. Systemic treatments are important to maintain control of central nervous system disease and improve patients' survival. BCBM medical treatment is a rapidly advancing area of research. With the emergence of new targeted drugs, more options are provided for the treatment of BM. This review features currently available BCBM treatment strategies and outlines novel drugs and ongoing clinical trials that may be available in the future. These treatment strategies are discovered to be more efficacious and potent, and present a paradigm shift in the management of BCBMs.

引用

页数：12

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