Early IgG/IgA response in hospitalized COVID-19 patients is associated with a less severe disease

被引：0

作者：

Fedele, Giorgio ^{[1
]}

Russo, Gianluca ^{[3
]}

Schiavoni, Ilaria ^{[1
]}

Leone, Pasqualina ^{[1
]}

Olivetta, Eleonora ^{[2
]}

Perri, Valentina ^{[3
]}

Zingaropoli, Maria Antonella ^{[3
]}

Ciardi, Maria Rosa ^{[3
]}

Pasculli, Patrizia ^{[3
]}

Mastroianni, Claudio Maria ^{[3
]}

Stefanelli, Paola ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Infect Dis, Rome, Italy

[2] Ist Super Sanita, Natl Ctr Global Hlth, Rome, Italy

[3] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, Rome, Italy

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2023年 / 105卷 / 01期

关键词：

SARS-CoV-2; COVID-19; Serology; Disease Severity; T-cell immunity; SARS-COV-2;

D O I：

10.1016/j.diagmicrobio.2021.115539

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We determined the kinetics of anti-SARS-CoV-2 antibody response in fifteen hospitalized COVID-19 patients. Patients were divided into mild/moderate (mild, n = 1; moderate, n = 4) or severe (n = 10) and virus-specific anti-Nucleocapsid IgM, anti-Spike IgG and anti-Spike IgA were measured in serial serum samples collected 0 to 15 days after hospital admission. Surrogate neutralization assays were performed by testing inhibition of ACE-2 binding to Spike. In 3 patients (2 severe and 1 moderate case), serum antibodies and T-cell memory were monitored 6 months after baseline. Although IgM response tended to appear first, patients affected by less severe disease were more prone to an early IgG/IgA response. Neutralization of Spike binding to ACE2 correlated with anti-Spike IgG and IgA. IgG and IgA antibody response persisted at the 6 months follow-up. A recall T-cell response to the Spike antigen was observed in 2 out of 3 patients, not related to disease severity. (c) 2021 Elsevier Inc. All rights reserved.

引用

页数：6

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