The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

被引：108

作者：

Alexander, Stephen P. H. ^{[1
]}

Mathie, Alistair A. ^{[2
]}

Peters, John A. ^{[3
]}

Veale, Emma L. ^{[4
,5
]}

Striessnig, Joerg ^{[6
]}

Kelly, Eamonn ^{[7
]}

Armstrong, Jane F. ^{[8
]}

Faccenda, Elena ^{[8
]}

Harding, Simon D. ^{[8
]}

Davies, Jamie A. ^{[8
]}

Aldrich, Richard W. ^{[9
]}

Attali, Bernard ^{[10
]}

Baggetta, Austin M. ^{[11
]}

Becirovic, Elvir ^{[12
]}

Biel, Martin ^{[12
]}

Bill, Roslyn M. ^{[13
]}

Caceres, Ana I. ^{[14
]}

Catterall, William A. ^{[15
]}

Conner, Alex C. ^{[16
]}

Davies, Paul ^{[17
]}

De Clerq, Katrien ^{[18
]}

Delling, Markus ^{[19
]}

Di Virgilio, Francesco ^{[20
]}

Falzoni, Simonetta ^{[20
]}

Fenske, Stefanie ^{[12
]}

Fortuny-Gomez, Anna ^{[21
]}

Fountain, Samuel ^{[21
]}

George, Chandy ^{[22
]}

Goldstein, Steve A. N. ^{[23
]}

Grimm, Christian ^{[12
]}

Grissmer, Stephan ^{[24
]}

Ha, Kotdaji ^{[19
]}

Hammelmann, Verena ^{[12
]}

Hanukoglu, Israel ^{[25
]}

Hu, Meiqin

Ijzerman, Ad P. ^{[26
]}

Jabba, Sairam V. ^{[14
]}

Jarvis, Mike ^{[27
]}

Jensen, Anders A. ^{[28
]}

Jordt, Sven E. ^{[14
]}

Kaczmarek, Leonard K. ^{[29
]}

Kellenberger, Stephan ^{[30
]}

Kennedy, Charles ^{[31
]}

King, Brian ^{[32
]}

Kitchen, Philip ^{[13
]}

Liu, Qiang

Lynch, Joseph W. ^{[33
]}

Meades, Jessica ^{[21
]}

Mehlfeld, Verena ^{[12
]}

Nicke, Annette ^{[12
]}

机构：

[1] Univ Nottingham, Med Sch, Sch Life Sci, Nottingham NG7 2UH, England

[2] Univ Suffolk, Sch Engn Arts Sci & Technol, Ipswich IP4 1QJ, Suffolk, England

[3] Univ Dundee, Ninewells Hosp & Med Sch, Med Educ Inst, Neurosci Div, Dundee DD1 9SY, Scotland

[4] Univ Greenwich, Medway Sch Pharm, Anson Bldg,Cent Ave, Chatham ME4 4TB, Kent, England

[5] Univ Kent Medway, Medway Sch Pharm, Anson Bldg,Cent Ave, Chatham ME4 4TB, Kent, England

[6] Univ Innsbruck, Pharmacol & Toxicol Inst Pharm, A-6020 Innsbruck, Austria

[7] Univ Bristol, Sch Physiol Pharmacol & Neurosci, Bristol BS8 1TD, Avon, England

[8] Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland

[9] Stanford Univ, Austin, TX USA

[10] Tel Aviv Univ, Tel Aviv, Israel

[11] Northeastern Univ, Boston, MA USA

[12] Ludwig Maximilian Univ Munich, Munich, Germany

[13] Aston Univ, Birmingham, W Midlands, England

[14] Duke Univ, Durham, NC USA

[15] Univ Washington, Seattle, WA USA

[16] Univ Birmingham, Birmingham, W Midlands, England

[17] Tufts Univ, Sch Med, Boston, MA USA

[18] Katholieke Univ Leuven, Leuven, Belgium

[19] Univ Calif San Francisco, San Francisco, CA USA

[20] Univ Ferrara, Ferrara, Italy

[21] Univ East Anglia, Norwich, Norfolk, England

[22] Nanyang Technol Univ, Singapore, Singapore

[23] Univ Calif Irvine, Irvine, CA USA

[24] Ulm Univ, Ulm, Germany

[25] Ariel Univ, Ariel, Israel

[26] Leiden Univ, Leiden, Netherlands

[27] Univ Illinois, Chicago, IL USA

[28] Univ Copenhagen, Copenhagen, Denmark

[29] Yale Univ, New Haven, CT USA

[30] Univ Lausanne, Lausanne, Switzerland

[31] Strathclyde Univ, Glasgow, Lanark, Scotland

[32] UCL, London, England

[33] Univ Queensland, Brisbane, Qld, Australia

[34] Goethe Univ Frankfurt, Max Planck Inst Heart & Lung Res, Bad Nauheim, Germany

[35] Univ Virginia, Charlottesville, VA USA

[36] Univ Queensland, St Lucia, Qld, Australia

[37] Univ Penn, Philadelphia, PA USA

[38] Univ Oxford, Oxford, England

[39] Med Univ Vienna, Vienna, Austria

[40] Univ British Columbia, Vancouver, BC, Canada

[41] Univ Texas Houston, Houston, TX USA

[42] Univ Calif Davis, Davis, CA USA

[43] Univ Michigan, Ann Arbor, MI USA

[44] Univ Connecticut, Farmington, CT USA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2023年 / 180卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1111/bph.16178

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at . Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

引用

页码：S145 / S222

页数：78