What Does the Future Hold for Biomarkers of Response to Extracorporeal Photopheresis for Mycosis Fungoides and Sézary Syndrome?

被引：2

作者：

Akilov, Oleg E. ^{[1
]}

机构：

[1] Univ Pittsburgh, Cutaneous Lymphoma Program, Pittsburgh, PA 15213 USA

来源：

CELLS | 2023年 / 12卷 / 18期

关键词：

biomarker; ECP; extracorporeal photopheresis; mycosis fungoides; Sezary syndrome; T-CELL LYMPHOMA; SEZARY-SYNDROME; EXPRESSION; LYMPHOCYTES; APOPTOSIS; PATHWAY; DEATH; STAGE; IMMUNOTHERAPY; PREDICTORS;

D O I：

10.3390/cells12182321

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Extracorporeal photopheresis (ECP) is an FDA-approved immunotherapy for cutaneous T-cell lymphoma, which can provide a complete response in some patients. However, it is still being determined who will respond well, and predictive biomarkers are urgently needed to target patients for timely treatment and to monitor their response over time. The aim of this review is to analyze the current state of the diagnostic, prognostic, and disease state-monitoring biomarkers of ECP, and outline the future direction of the ECP biomarker discovery. Specifically, we focus on biomarkers of response to ECP in mycosis fungoides and Sezary syndrome. The review summarizes the current knowledge of ECP biomarkers, including their limitations and potential applications, and identifies key challenges in ECP biomarker discovery. In addition, we discuss emerging technologies that could revolutionize ECP biomarker discovery and accelerate the translation of biomarker research into clinical practice. This review will interest researchers and clinicians seeking to optimize ECP therapy for cutaneous T-cell lymphoma.

引用

页数：14

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