The Cost-Effectiveness of the BEAT-TB Regimen for Pre-Extensively Drug-Resistant TB

被引：3

作者：

Muniyandi, Malaisamy ^{[1
]}

Ramesh, Paranchi Murugesan ^{[2
]}

Wells, William A. ^{[3
]}

Alavadi, Umesh ^{[4
]}

Sahu, Suvanand ^{[5
]}

Padmapriyadarsini, Chandrasekaran ^{[1
]}

机构：

[1] ICMR Natl Inst Res TB, Chennai 600031, India

[2] Govt Ottery TB Hosp, Chennai 600012, India

[3] USAID, Washington, DC 20004 USA

[4] united States Agcy Int Dev USAID, New Delhi 110021, Delhi, India

[5] Stop TB Partnership Secretariat, CH-1218 Geneva, Switzerland

来源：

TROPICAL MEDICINE AND INFECTIOUS DISEASE | 2023年 / 8卷 / 08期

关键词：

tuberculosis; infectious diseases; economic impact; pre-XDR-TB treatment regimen; shorter BEAT-TB India regimen; societal perspective; cost-effective BEAT-TB regimen; TUBERCULOSIS;

D O I：

10.3390/tropicalmed8080411

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objective: To measure the economic impacts of the longer pre-XDR-TB treatment regimen and the shorter BEAT-TB India regimen. Methods: In the current study, the economic impacts of the current 18-month pre-XDR-TB treatment regimen and the 6-9 month BEAT-TB regimen were evaluated using an economic model via a decision tree analysis from a societal perspective. The incremental costs and quality-adjusted life years (QALYs) gained from the introduction of the BEAT-TB regimen for pre-XDR-TB patients were estimated. Results: For a cohort of 1000 pre-XDR-TB patients, we found that the BEAT-TB India regimen yielded higher undiscounted life years (40,548 vs. 21,009) and more QALYs gained (27,633 vs. 15,812) than the 18-month regimen. The BEAT-TB India regimen was found to be cost-saving, with an incremental cost of USD -128,651 when compared to the 18-month regimen. The current analysis did not consider the possibility of reduced TB recurrence after use of the BEAT-TB regimen, so it might have under-estimated the benefits. Conclusion: As a lower-cost intervention with improved health outcomes, the BEAT-TB India regimen is dominant when compared to the 18-month regimen.

引用

页数：10

共 21 条

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