Progress in self-healing hydrogels and their applications in bone tissue engineering

被引：24

作者：

Erezuma, Itsasne ^{[1
,2
]}

Lukin, Izeia ^{[1
,2
]}

Desimone, Martin ^{[3
]}

Zhang, Yu Shrike ^{[4
]}

Dolatshahi-Pirouz, Alireza ^{[5
]}

Orive, Gorka ^{[1
,2
,6
,7
,8
]}

机构：

[1] Univ Basque Country UPV EHU, Sch Pharm, NanoBioCel Res Grp, Vitoria, Spain

[2] Bioaraba, NanoBioCel Res Grp, Vitoria, Spain

[3] Univ Buenos Aires, Fac Farm & Bioquim, CONICET, Inst Quim & Metab Farm IQUIMEFA, Buenos Aires, Argentina

[4] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA

[5] Tech Univ Denmark, Dept Hlth Technol, DK-2800 Lyngby, Denmark

[6] Biomed Res Networking Ctr Bioengn Biomat & Nanomed, Vitoria, Spain

[7] Univ Inst Regenerat Med & Oral Implantol UIRMI, UPV EHU Fdn Eduardo Anitua, Vitoria 01007, Spain

[8] The Acad, Singapore Eye Res Inst, 20 Coll Rd,Discovery Tower, Singapore 169856, Singapore

来源：

BIOMATERIALS ADVANCES | 2023年 / 146卷

关键词：

Self-healing; Bone tissue engineering; Hydrogel; Biomaterials; SILK FIBROIN; REGENERATION; SCAFFOLDS; CELLS; DIFFERENTIATION; BEHAVIOR;

D O I：

10.1016/j.bioadv.2022.213274

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Bone tissue engineering (BTE) is constantly seeking novel treatments to address bone injuries in all their vari-eties. It is necessary to find new ways to create structures that perfectly emulate the native tissue. Self-healing hydrogels have been a breakthrough in this regard, as they are able to reconstitute their links after they have been partially broken. Among the most outstanding biomaterials when it comes to developing these hydrogels for BTE, those polymers of natural origin (e.g., gelatin, alginate) stand out, although synthetics such as PEG or nanomaterials like laponite are also key for this purpose. Self-healing hydrogels have proven to be efficient in healing bone, but have also played a key role as delivery-platforms for drugs or other biological agents. More-over, some researchers have identified novel uses for these gels as bone fixators or implant coatings. Here, we review the progress of self-healing hydrogels, which hold great promise in the field of tissue engineering.

引用

页数：12

共 98 条

[1]

Andersen T, 2011, SPR CARB CH, V37, P227, DOI 10.1039/9781849732765-00227

[2] A bioinspired mineral-organic composite hydrogel as a self-healable and mechanically robust bone graft for promoting bone regeneration [J].