Impact of Immunomodulatory Therapy on COVID-19 Vaccine Response in Patients with Autoimmune Inflammatory Rheumatic Diseases

被引:4
作者
Yap, Ruth Xian Lynn [1 ]
Lai, Yi Wye [1 ]
Wei, Chang [2 ]
Ng, Joel Jia Wei [3 ]
Xu, Dan [2 ]
Feng, Shuo [4 ]
Mu, Rong [2 ]
Thong, Bernard Yu-Hor [1 ]
Xu, Chuanhui [1 ]
机构
[1] Tan Tock Seng Hosp, Dept Rheumatol Allergy & Immunol, Singapore 308433, Singapore
[2] Peking Univ Third Hosp, Dept Rheumatol & Immunol, Beijing 100191, Peoples R China
[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 119077, Singapore
[4] Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford OX1 2JD, England
关键词
vaccination; COVID-19; autoimmune inflammatory rheumatic disease; immunogenicity; METHOTREXATE;
D O I
10.3390/vaccines12030274
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Coronavirus disease 2019 (COVID-19) vaccination is essential for patients with autoimmune inflammatory rheumatic diseases (AIIRD) to reduce the risk of morbidity and mortality associated with serious COVID-19 infection. With endemicity, waning of vaccine- and infection-acquired immunity, and development of SARS-CoV-2 variants, the need for additional doses of vaccines against serious illness in high-risk immunocompromised persons remains imperative. This review examines how immunomodulatory therapies affect vaccine-induced immune response in patients with AIIRD. Glucocorticoids, methotrexate, azathioprine, calcineurin inhibitors, mycophenolate mofetil, tumor necrosis factor inhibitors, and abatacept have been shown to variably attenuate both humoral and cellular immune responses to vaccination. Janus kinase inhibitors reduce humoral immune response. In contrast, sulfasalazine, leflunomide, belimumab, interleukin (IL)-17, IL-12/23, IL-6, and IL-1 inhibitors appear favorable, with mild or no impact on vaccine response. Although rituximab is known to profoundly diminish humoral immune response, cellular immunity is relatively preserved. Administering a third and subsequent vaccine dose or temporally coordinating the dosing of immunomodulatory drugs may improve vaccine effectiveness. Further research is needed to personalise vaccination strategies for AIIRD patients, considering their specific immunomodulatory treatments.
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页数:12
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  • [1] Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial
    Abhishek, Abhishek
    Boyton, Rosemary J.
    Peckham, Nicholas
    McKnight, Aine
    Coates, Laura C.
    Bluett, James
    Barber, Vicki
    Cureton, Lucy
    Francis, Anne
    Appelbe, Duncan
    Eldridge, Lucy
    Julier, Patrick
    Valdes, Ana M.
    Brooks, Tim
    Rombach, Ines
    Altmann, Daniel M.
    Nguyen-Van-Tam, Jonathan S.
    Williams, Hywel C.
    Cook, Jonathan A.
    [J]. LANCET RESPIRATORY MEDICINE, 2022, 10 (09) : 840 - 850
  • [2] Strong response after fourth dose of mRNA COVID-19 vaccine in autoimmune rheumatic diseases patients with poor response to inactivated vaccine
    Aikawa, Nadia E.
    Kupa, Leonard V. K.
    Silva, Clovis A.
    Saad, Carla G. S.
    Pasoto, Sandra G.
    Yuki, Emily F. N.
    Fusco, Solange R. G.
    Shinjo, Samuel K.
    Andrade, Danieli C. O.
    Sampaio-Barros, Percival D.
    Pereira, Rosa M. R.
    Chasin, Anna C. S.
    Shimabuco, Andrea Y.
    Luppino-Assad, Ana P.
    Leon, Elaine P.
    Lopes, Marta H.
    Antonangelo, Leila
    Medeiros-Ribeiro, Ana C.
    Bonfa, Eloisa
    [J]. RHEUMATOLOGY, 2022, 62 (01) : 480 - 485
  • [3] Increment of immunogenicity after third dose of a homologous inactivated SARS-CoV-2 vaccine in a large population of patients with autoimmune rheumatic diseases
    Aikawa, Nadia Emi
    Kanda Kupa, Leonard de Vinci
    Medeiros-Ribeiro, Ana Cristina
    Schahin Saad, Carla Goncalves
    Neves Yuki, Emily Figueiredo
    Pasoto, Sandra Gofinet
    Rojo, Priscila Tagliaferro
    Rodrigues Pereira, Rosa Maria
    Shinjo, Samuel Katsuyuki
    Sampaio-Barros, Percival Degrava
    Oliveira Andrade, Danieli Castro
    Radu Halpern, Ari Stiel
    Fuller, Ricardo
    Carlos Souza, Fernando Henrique
    Noronha Guedes, Lissiane Karine
    Assad, Ana Paula Luppino
    Bertacini de Moraes, Julio Cesar
    Ugolini Lopes, Michelle Remiao
    de Oliveira Martins, Victor Adriano
    Betancourt, Lorena
    Ribeiro, Carolina Torres
    Sales, Lucas Peixoto
    Bertoglio, Isabela Maria
    Nazario Bonoldi, Virginia Lucia
    Pinheiro Mello, Renata Lys
    Moreira Balbi, Gustavo Guimaraes
    Christovam Sartori, Ana Marli
    Antonangelo, Leila
    Silva, Clovis Artur
    Bonfa, Eloisa
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2022, 81 (07) : 1036 - 1043
  • [4] Different humoral but similar cellular responses of patients with autoimmune inflammatory rheumatic diseases under disease-modifying antirheumatic drugs after COVID-19 vaccination
    Andreica, Ioana
    Blazquez-Navarro, Arturo
    Sokolar, Jan
    Anft, Moritz
    Kiltz, Uta
    Pfaender, Stephanie
    Blanco, Elena Vidal
    Westhoff, Timm
    Babel, Nina
    Stervbo, Ulrik
    Baraliakos, Xenofon
    [J]. RMD OPEN, 2022, 8 (02):
  • [5] Serological response to SARS-CoV-2 vaccination in patients with inflammatory rheumatic disease treated with disease modifying anti-rheumatic drugs: A cohort study and a meta-analysis
    Auroux, Maxime
    Laurent, Benjamin
    Coste, Baptiste
    Massy, Emmanuel
    Mercier, Alexandre
    Durieu, Isabelle
    Confavreux, Cyrille B.
    Lega, Jean-Christophe
    Mainbourg, Sabine
    Coury, Fabienne
    [J]. JOINT BONE SPINE, 2022, 89 (05)
  • [6] Belimumab is not associated with COVID-19 mRNA vaccination failure in systemic lupus erythematosus
    Boedecker-Lips, Simone Cosima
    Classen, Paul
    Kraus, Daniel
    Weinmann-Menke, Julia
    [J]. RHEUMATOLOGY, 2023, 62 (03) : E34 - E35
  • [7] Mycophenolate mofetil, azathioprine and tacrolimus: mechanisms in rheumatology
    Broen, Jasper C. A.
    van Laar, Jacob M.
    [J]. NATURE REVIEWS RHEUMATOLOGY, 2020, 16 (03) : 167 - 178
  • [8] Response to Vaccination Against SARS-CoV-2 in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis With Renal Involvement
    Carruthers, Jack E.
    Wells, James
    Gupta, Arun
    Kallon, Delordson
    Cox, Amber
    Pina, Neuza
    Yaqoob, Muhammad Magdi
    Rajakariar, Ravindra
    [J]. FRONTIERS IN MEDICINE, 2022, 8
  • [9] The interaction properties of costimulatory molecules revisited
    Collins, AV
    Brodie, DW
    Gilbert, RJC
    Iaboni, A
    Manso-Sancho, R
    Walse, B
    Stuart, DI
    van der Merwe, PA
    Davis, SJ
    [J]. IMMUNITY, 2002, 17 (02) : 201 - 210
  • [10] Methotrexate and its mechanisms of action in inflammatory arthritis
    Cronstein, Bruce N.
    Aune, Thomas M.
    [J]. NATURE REVIEWS RHEUMATOLOGY, 2020, 16 (03) : 145 - 154