The Optimal Targeting for Focused Ultrasound Thalamotomy Differs between Dystonic and Essential Tremor: A 12-Month Prospective Pilot Study

被引：5

作者：

Andreasi, Nico Golfre ^{[1
]}

Braccia, Arianna ^{[1
]}

Levi, Vincenzo ^{[2
]}

Rinaldo, Sara ^{[1
]}

Ghielmetti, Francesco ^{[3
]}

Cilia, Roberto ^{[1
,11
]}

Romito, Luigi Michele ^{[1
]}

Bonvegna, Salvatore ^{[1
,12
]}

Elia, Antonio Emanuele ^{[1
]}

Devigili, Grazia ^{[1
]}

Telese, Roberta ^{[1
]}

Colucci, Fabiana ^{[1
]}

Bruzzone, Maria Grazia ^{[4
]}

Messina, Giuseppe ^{[2
]}

Corradi, Marta ^{[1
]}

Stanziano, Mario ^{[4
,5
]}

Caldiera, Valentina ^{[6
]}

Prioni, Sara ^{[7
]}

Amami, Paolo ^{[7
]}

Fusar Poli, Marco ^{[7
]}

Piacentini, Sylvie Helene Marie Jeanne ^{[7
]}

Grisoli, Marina ^{[4
]}

Ciceri, Elisa Francesca Maria

DiMeco, Francesco ^{[8
,9
,10
]}

Eleopra, Roberto ^{[1
]}

机构：

[1] Fdn IRCCS Ist Neurol Carlo Besta, Dept Clin Neurosci, Parkinson & Movement Disorders Unit, Milan, Italy

[2] Fdn IRCCS Ist Neurol Carlo Besta, Dept Neurosurg, Funct Neurosurg Unit, Milan, Italy

[3] Fdn IRCCS Ist Neurol Carlo Besta, Hlth Dept, Milan, Italy

[4] Fdn IRCCS Ist Neurol Carlo Besta, Neuroradiol Unit, Milan, Italy

[5] Univ Turin, Neurosci Dept Rita Levi Montalcini, Turin, Italy

[6] Fdn IRCCS Ist Neurol Carlo Besta, Diagnost Radiol & Intervent Neuroradiol, Milan, Italy

[7] Fdn IRCCS Ist Neurol Carlo Besta, Clin Neuropsychol Unit, Milan, Italy

[8] Fdn IRCCS Ist Neurol Carlo Besta, Dept Neurosurg, Milan, Italy

[9] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy

[10] Johns Hopkins Med Sch, Dept Neurol Surg, Hunterian Brain Tumor Res Lab, Baltimore, MD USA

[11] Fdn IRCCS Ist Neurol Carlo Besta, Dept Clin Neurosci, Parkinson & Movement Disorders Unit, Via Celoria 11, I-20133 Milan, Italy

[12] ASST Gaetano Pini CTO, Parkinson Inst, Milan, Italy

来源：

MOVEMENT DISORDERS CLINICAL PRACTICE | 2024年 / 11卷 / 01期

关键词：

MRgFUS; thalamotomy; essential tremor; dystonic tremor; dystonia; DEEP BRAIN-STIMULATION; CONSENSUS STATEMENT; PARKINSON; LOCATION; OUTCOMES; TRIAL; SCALE; AREA;

D O I：

10.1002/mdc3.13911

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BackgroundMagnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is increasingly used to treat drug-resistant essential tremor (ET). Data on MRgFUS thalamotomy in dystonic tremor (DT) are anecdotal.ObjectivesTo investigate efficacy, safety, and differences in target coordinates of MRgFUS thalamotomy in DT versus ET.MethodsTen patients with DT and 35 with ET who consecutively underwent MRgFUS thalamotomy were followed for 12 months. Although in both groups the initial surgical planning coordinates corresponded to the ventralis intermediate (Vim), the final target could be modified intraoperatively based on clinical response.ResultsTremor significantly improved in both groups. The thalamic lesion was significantly more anterior in DT than ET. Considering both ET and DT groups, the more anterior the lesion, the lower the odds ratio for adverse events.ConclusionsMRgFUS thalamotomy is safe and effective in DT and ET. Compared to classical Vim coordinates used for ET, more anterior targeting should be considered for DT.

引用

页码：69 / 75

页数：7

共 41 条

[1] Magnetic Resonance-Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early-Stage Tremor-Dominant Parkinson's Disease: A Pilot Study [J].

Andreasi, Nico Golfre ;

Cilia, Roberto ;

Romito, Luigi Michele ;

Bonvegna, Salvatore ;

Straccia, Giulia ;

Elia, Antonio Emanuele ;

Novelli, Alessio ;

Messina, Giuseppe ;

Tringali, Giovanni ;

Levi, Vincenzo ;

Devigili, Grazia ;

Rinaldo, Sara ;

Gasparini, Valentina ;

Grisoli, Marina ;

Stanziano, Mario ;

Ghielmetti, Francesco ;

Prioni, Sara ;

Bocchi, Elisa ;

Amami, Paolo ;

Jeanne Piacentini, Sylvie Helene Marie ;

Maria Ciceri, Elisa Francesca ;

Bruzzone, Maria Grazia ;

Eleopra, Roberto .

MOVEMENT DISORDERS, 2022, 37 (11) :2289-2295

[2] Consensus Statement on the Classification of Tremors. From the Task Force on Tremor of the International Parkinson and Movement Disorder Society [J].

Bhatia, Kailash P. ;

Bain, Peter ;

Bajaj, Nin ;

Elble, Rodger J. ;

Hallett, Mark ;

Louis, Elan D. ;

Raethjen, Jan ;

Stamelou, Maria ;

Testa, Claudia M. ;

Deuschl, Guenther .

MOVEMENT DISORDERS, 2018, 33 (01) :75-87

[3] Safety and Efficacy of Focused Ultrasound Thalamotomy for Patients With Medication-Refractory, Tremor-Dominant Parkinson Disease A Randomized Clinical Trial [J].

Bond, Aaron E. ;

Shah, Binit B. ;

Huss, Diane S. ;

Dallapiazza, Robert F. ;

Warren, Amy ;

Harrison, Madaline B. ;

Sperling, Scott A. ;

Wang, Xin-Qun ;

Gwinn, Ryder ;

Witt, Jennie ;

Ro, Susie ;

Elias, W. Jeffrey .

JAMA NEUROLOGY, 2017, 74 (12) :1412-1418

[4] Focused ultrasound thalamotomy location determines clinical benefits in patients with essential tremor [J].

Boutet, Alexandre ;

Ranjan, Manish ;

Zhong, Jidan ;

Germann, Jurgen ;

Xu, David ;

Schwartz, Michael L. ;

Lipsman, Nir ;

Hynynen, Kullervo ;

Devenyi, Gabriel A. ;

Chakravarty, Mallar ;

Hlasny, Eugen ;

Llinas, Maheleth ;

Lozano, Christopher S. ;

Elias, Gavin J. B. ;

Chan, Jason ;

Coblentz, Ailish ;

Fasano, Alfonso ;

Kucharczyk, Walter ;

Hodaie, Mojgan ;

Lozano, Andres M. .

BRAIN, 2018, 141 :3405-3414

[5] A Prospective Trial of Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor: Results at the 2-Year Follow-up [J].

Chang, Jin Woo ;

Park, Chang Kyu ;

Lipsman, Nir ;

Schwartz, Michael L. ;

Ghanouni, Pejman ;

Henderson, Jaimie M. ;

Gwinn, Ryder ;

Witt, Jennifer ;

Tierney, Travis S. ;

Cosgrove, G. Rees ;

Shah, Binit B. ;

Abe, Keiichi ;

Taira, Takaomi ;

Lozano, Andres M. ;

Eisenberg, Howard M. ;

Fishman, Paul S. ;

Elias, W. Jeffrey .

ANNALS OF NEUROLOGY, 2018, 83 (01) :107-114

[6] Unilateral magnetic resonance guided focused ultrasound thalamotomy for essential tremor: practices and clinicoradiological outcomes [J].

Chang, Won Seok ;

Jung, Hyun Ho ;

Kweon, Eun Jung ;

Zadicario, Eyal ;

Rachmilevitch, Itay ;

Chang, Jin Woo .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2015, 86 (03) :257-264

[7] Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results [J].

Cosgrove, G. Rees ;

Lipsman, Nir ;

Lozano, Andres M. ;

Chang, Jin Woo ;

Halpern, Casey ;

Ghanouni, Pejman ;

Eisenberg, Howard ;

Fishman, Paul ;

Taira, Takaomi ;

Schwartz, Michael L. ;

McDannold, Nathan ;

Hayes, Michael ;

Ro, Susie ;

Shah, Binit ;

Gwinn, Ryder ;

Santini, Veronica E. ;

Hynynen, Kullervo ;

Elias, W. Jeff .

JOURNAL OF NEUROSURGERY, 2022, 138 (04) :1028-1033

[8] Consensus statement of the Movement Disorder Society on tremor [J].

Deuschl, G ;

Bain, P ;

Brin, M .

MOVEMENT DISORDERS, 1998, 13 :2-23

[9] Reliability of a new scale for essential tremor [J].

Elble, Rodger ;

Comella, Cynthia ;

Fahn, Stanley ;

Hallett, Mark ;

Jankovic, Joseph ;

Juncos, Jorge L. ;

LeWitt, Peter ;

Lyons, Kelly ;

Ondo, William ;

Pahwa, Rajesh ;

Sethi, Kapil ;

Stover, Natividad ;

Tarsy, Daniel ;

Testa, Claudia ;

Tintner, Ron ;

Watts, Ray ;

Zesiewicz, Theresa .

MOVEMENT DISORDERS, 2012, 27 (12) :1567-1569

[10] A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor [J].

Elias, W. Jeffrey ;

Lipsman, Nir ;

Ondo, William G. ;

Ghanouni, Pejman ;

Kim, Young G. ;

Lee, Wonhee ;

Schwartz, Michael ;

Hynynen, Kullervo ;

Lozano, Andres M. ;

Shah, Binit B. ;

Huss, Diane ;

Dallapiazza, Robert F. ;

Gwinn, Ryder ;

Witt, Jennifer ;

Ro, Susie ;

Eisenberg, Howard M. ;

Fishman, Paul S. ;

Gandhi, Dheeraj ;

Halpern, Casey H. ;

Chuang, Rosalind ;

Pauly, Kim Butts ;

Tierney, Travis S. ;

Hayes, Michael T. ;

Cosgrove, G. Rees ;

Yamaguchi, Toshio ;

Abe, Keiichi ;

Taira, Takaomi ;

Chang, Jin W. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (08) :730-739

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