Cell Based IL12 Immunomodulation Combined with PD-1 Inhibition Generates Local and Abscopal Immune Activation to Eradicate Metastatic Pancreatic Cancer

被引：0

作者：

Veiseh, Omid ^{[1
]}

机构：

[1] Rice Univ, Bioengn, Houston, TX USA

来源：

MOLECULAR THERAPY | 2023年 / 31卷 / 04期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

1032

引用

页码：496 / 496

页数：1

共 12 条

[1] Cell-generated IL12 combined with PD-1 inhibition produces local and abscopal immune activation to eradicate metastatic melanoma and pancreatic cancer
Nash, Amanda
Castillo, Bertha
Murungi, Danna
Reticker-Flynn, Nathan
Veiseh, Omid
CANCER RESEARCH, 2023, 83 (08)
[2] Combined inhibition of CXCL12 and PD-1 in MSS colorectal and pancreatic cancer: modulation of the microenvironment and clinical effects
Suarez-Carmona, Meggy
Williams, Anja
Schreiber, Jutta
Hohmann, Nicolas
Pruefer, Ulrike
Krauss, Juergen
Jaeger, Dirk
Froemming, Anna
Beyer, Diana
Eulberg, Dirk
Jungelius, Jarf Ulf
Baumann, Matthias
Mangasarian, Aram
Halama, Niels
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 (10)
[3] Combined immunotherapy for metastatic triple-negative breast cancer based on PD-1/PD-L1 immune checkpoint blocking
He, Rui
Yuan, Xing
Chen, Zeran
Zheng, Yongfeng
INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 113
[4] B cell immunology predict response and survival in PD-1/PD-L1 targeting immune checkpoint inhibition of metastatic breast cancer
Fremd, Carlo
Schulze, Markus
Cetin, Miray
Boehm, Hannah
Lenoire, Benedicte
Akilli-Oeztuerk, Oezlem
Zornig, Inka
Charoentong, Pornpimol
Lyu, Yanhong
Hubschmann, Daniel
Hubschmann, Daniel
Kommoss, Felix
Thewes, Verena
Schneeweiss, Andreas
Zapatka, Marc
Hartmann, Felix
Lichter, Peter
CANCER RESEARCH, 2024, 84 (09)
[5] Immunotherapy with IL12 and PD1/CTLA4 inhibition is effective in advanced ovarian cancer and associates with reversal of myeloid cell-induced immunosuppression
Pavicic Jr, Paul G. G.
Rayman, Patricia A.
Swaidani, Shadi
Rupani, Amit
Makarov, Vladimir
Tannenbaum, Charles S.
Edwards, Robert P.
Vlad, Anda M.
Diaz-Montero, C. Marcela
Mahdi, Haider
ONCOIMMUNOLOGY, 2023, 12 (01):
[6] Targeting IL-1B synergizes with PD-1 blockade for enhanced T and B cell immune responses and inhibition of early lung cancer development
Treekitkarnmongkol, Warapen
Han, Guangchun
Rahal, Zahraa
Feng, Jiping
Sinjab, Ansam
Cascone, Tina
Stevenson, Christopher S.
Sweeney, Cheryl
Edwards, Matt
Spira, Avrum
Fujimoto, Junya
Moghaddam, Seyed Javad
Wang, Linghua
Kadara, Humam
CANCER RESEARCH, 2023, 83 (07)
[7] Autologous ex vivo expanded NK cells combined with PD-1 inhibitor improved ascitic fluid immune microenvironment of peritoneal metastatic pancreatic cancer: a case study
Chen, Ling
Qian, Yuping
Guo, Meng
Liu, Yanfang
Li, Jie
Wu, Meihong
Zhang, Yingyi
Wang, Yujie
Peng, Xiaobo
Zhan, Xianbao
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2023, 15 (01): : 316 - +
[8] PD-1 Inhibitor Combined with Radiotherapy and GM-CSF with or not IL-2 (PRaG Regimen) for Advanced Metastatic Non-Small Cell Lung Cancer
Zhou, W.
Kong, Y.
LiYuan, Z.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2022, 114 (03): : E402 - E402
[9] T cell activation with systemic agonistic antibody versus local 4-1BB ligand gene delivery combined with interleukin-12 eradicate liver metastases of breast cancer
Martinet, O
Divino, CM
Zang, Y
Gan, Y
Mandeli, J
Thung, S
Pan, PY
Chen, SH
GENE THERAPY, 2002, 9 (12) : 786 - 792
[10] T cell activation with systemic agonistic antibody versus local 4-1BB ligand gene delivery combined with interleukin-12 eradicate liver metastases of breast cancer
O Martinet
CM Divino
Y Zang
Y Gan
J Mandeli
S Thung
P-Y Pan
S-H Chen
Gene Therapy, 2002, 9 : 786 - 792

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