T follicular helper cells and T follicular regulatory cells in autoimmune diseases

被引：46

作者：

Qi, Jingjing ^{[1
]}

Liu, Chang ^{[2
]}

Bai, Ziran ^{[1
]}

Li, Xia ^{[1
]}

Yao, Genhong ^{[3
]}

机构：

[1] Dalian Med Univ, Coll Basic Med Sci, Dept Immunol, Dalian, Liaoning, Peoples R China

[2] Dalian Municipal Cent Hosp, Dept Rheumatol & Immunol, Dalian, Liaoning, Peoples R China

[3] Nanjing Univ, Dept Rheumatol & Immunol, Affiliated Drum Tower Hosp, Med Sch, Nanjing, Jiangsu, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

T follicular helper cells (TFH cells); T follicular regulatory cells (TFR); autoimmune diseases; rheumatoid arthritis; systemic lupus erythematosus; Sjogren's syndrome; type; 1; diabetes; multiple sclerosis; PRIMARY SJOGRENS-SYNDROME; MULTIPLE-SCLEROSIS; B-CELLS; DIFFERENTIATION; BCL6; GENERATION; EXPRESSION; IL-21; INTERLEUKIN-21; EXPANSION;

D O I：

10.3389/fimmu.2023.1178792

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T follicular helper (Tfh) cells are heterogeneous and mainly characterized by expressing surface markers CXCR5, ICOS, and PD-1; cytokine IL-21; and transcription factor Bcl6. They are crucial for B-cell differentiation into long-lived plasma cells and high-affinity antibody production. T follicular regulatory (Tfr) cells were described to express markers of conventional T regulatory (Treg) cells and Tfh cells and were able to suppress Tfh-cell and B-cell responses. Evidence has revealed that the dysregulation of Tfh and Tfr cells is positively associated with the pathogenic processes of autoimmune diseases. Herein, we briefly introduce the phenotype, differentiation, and function of Tfh and Tfr cells, and review their potential roles in autoimmune diseases. In addition, we discuss perspectives to develop novel therapies targeting Tfh/Tfr balance.

引用

页数：11

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