Suppressive effects of violet light transmission on myopia progression in a mouse model of lens-induced myopia

被引：15

作者：

Jeong, Heonuk ^{[1
,2
]}

Kurihara, Toshihide ^{[1
,2
,5
]}

Jiang, Xiaoyan ^{[1
,2
]}

Kondo, Shinichiro ^{[3
]}

Ueno, Yusuke ^{[4
]}

Hayashi, Yuki ^{[4
]}

Lee, Deokho ^{[1
,2
]}

Ikeda, Shin-Ichi ^{[1
,2
]}

Mori, Kiwako ^{[1
,2
]}

Torii, Hidemasa ^{[1
,2
]}

Negishi, Kazuno ^{[2
]}

Tsubota, Kazuo ^{[2
,3
,6
]}

机构：

[1] Keio Univ, Lab Photobiol, Sch Med, 35 Shinanomachi,Shinjuku Ku, Tokyo 1608582, Japan

[2] Keio Univ, Dept Ophthalmol, Sch Med, 35 Shinanomachi,Shinjuku Ku, Tokyo 1608582, Japan

[3] Tsubota Lab Inc, 34 Shinanomachi,304 Toshin Shinanomachi Ekimae Bld, Tokyo 1600016, Japan

[4] Menicon Co Ltd, 21-19,Aoi 3,Naka Ku, Nagoya 4600006, Japan

[5] Keio Univ, Dept Ophthalmol, Lab Photobiol, Sch Med, 35 Shinanomachi,Shinjuku Ku, Tokyo 1608582, Japan

[6] Tsubota Lab Inc, 34 Shinanomachi,304 Toshin Shinanomachi Ekimae Bld, Tokyo 1600016, Japan

来源：

EXPERIMENTAL EYE RESEARCH | 2023年 / 228卷

关键词：

Myopia; Violet light; Lens transmission; Axial length; Choroidal thickness; CHOROIDAL BLOOD PERFUSION; DEPRIVATION MYOPIA; INCIDENT MYOPIA; TIME OUTDOORS; CHILDREN; PHOTOENTRAINMENT; SCHOOLCHILDREN; PREVALENCE; THICKNESS; SCHOOL;

D O I：

10.1016/j.exer.2023.109414

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The prevalence of myopia has been steadily increasing for several decades, and this condition can cause extensive medical and economic issues in society. Exposure to violet light (VL), a short wavelength (360-400 nm) of visible light from sunlight, has been suggested as an effective preventive and suppressive treatments for the develop-ment and progression of myopia. However, the clinical application of VL remains unclear. In this study, we aimed to investigate the preventive and suppressive effects of VL on myopia progression. Various transmittances of VL (40%, 70%, and 100%) were tested in C57BL/6J mice with lens-induced myopia (LIM). Changes in the refractive error, axial length, and choroid thickness during the 3-week LIM were measured. The myopic shift in refractive error and difference in axial length between the 0 and-30 diopter lens was lessened in a transmission-dependent manner. Choroidal thinning, which was observed in myopic conditions, was suppressed by VL exposure and affected by its transmission. The results suggest that myopia progression can be managed using VL transmittance. Therefore, these factors should be considered for the prevention and treatment of myopia.

引用

页数：6

共 52 条

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