Effects of osteogenic growth peptide C-terminal pentapeptide and its analogue on bone remodeling in an osteoporosis rat model

被引：2

作者：

Ma, Yuhang ^{[1
]}

Zhang, Ying ^{[1
]}

Lin, Yi ^{[1
]}

Ding, Xiaoying ^{[1
]}

Zhang, Yuntao ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Endocrinol & Metab, Shanghai 200080, Peoples R China

[2] Shanghai Urban Construct Vocat Coll, Sch Digital Construct, Shanghai 201999, Peoples R China

来源：

OPEN MEDICINE | 2023年 / 18卷 / 01期

基金：

中国国家自然科学基金;

关键词：

osteogenic growth peptide C-terminal pentapeptide; osteoporosis; bone mineral density; histomorphometry; biomechanical property; MESENCHYMAL STEM-CELLS; OSTEOBLASTS;

D O I：

10.1515/med-2023-0656

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study aimed to explore the effects of osteogenic growth peptide C-terminal pentapeptide (G36G), and its analog G48A on bone modeling in rats with ovariectomy-induced osteoporosis. Ovariectomized rats were administered PBS (OVX group), risedronate (RISE group), G36G combined with risedronate (36GRI group), G36G (G36G group), or G48A (G48A group). The sham-operation rats (SHAM group) were administered PBS. Serum osteocalcin and IGF-2 levels in the SHAM, OVX, G36G, G48A, and RISE groups were observably lower than the 36GRI group (P < 0.01) and the bone mineral density of the entire femur, distal metaphysis, and lumbar L1-L4 in the 36GRI group were notably increased (P < 0.05). The bending energy of the 36GRI group was prominently higher than the other groups (P < 0.05). Other features measured in the study that provided significant outcomes was the ratio of femora ash weight/dry weigh, parameters of trabecular bone volume (TBV)/total tissue volume, TBV/sponge bone volume, mean trabecular plate thickness, mean trabecular plate space, bone surface, parameters of sfract(s) and sfract(d), tetracycline-labeled, and osteoid surfaces. Bone loss in ovariectomized rats may be partially inhibited by G36G and G48A. A combination treatment with G36G and risedronate may be an effective intervention for osteoporosis.

引用

页数：8