The Burden of Non-Alcoholic Fatty Liver Disease in Adolescents with Polycystic Ovary Syndrome: A Case-Control Study

被引:12
作者
Giannouli, Aikaterini [1 ,2 ]
Efthymiou, Vasiliki [1 ,2 ]
Konidari, Marianna [3 ]
Mani, Iliana [4 ]
Aravantinos, Leon [5 ]
Dourakis, Spyridon P. [4 ]
Antoniou, Aristeidis [3 ]
Deligeoroglou, Efthymios [6 ]
Bacopoulou, Flora [1 ,2 ]
机构
[1] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Ctr Adolescent Med, Med Sch,Dept Pediat 1, 1 Thivon Str, Athens 11527, Greece
[2] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, UNESCO Chair Adolescent Hlth Care, Med Sch,Dept Pediat 1, 1 Thivon Str, Athens 11527, Greece
[3] Natl & Kapodistrian Univ Athens, Aretaieio Hosp, Med Sch, Dept Radiol 1, 76 Vassilisis Sofias Ave, Athens 11528, Greece
[4] Natl & Kapodistrian Univ Athens, Hippokratio Hosp, Med Sch, Res Lab,Dept Internal Med 2, Athens 11527, Greece
[5] Natl & Kapodistrian Univ Athens, Aretaieio Hosp, Med Sch, Dept Obstet & Gynecol 2, 76 Vassilisis Sofias Ave, Athens 11528, Greece
[6] Mitera Childrens Hosp, Dept Pediat & Adolescent Gynecol, Erythrou Stavrou, Athens 15123, Greece
关键词
adolescent; PCOS; polycystic ovary syndrome; fatty liver; NAFLD; MAFLD; non-alcoholic fatty liver disease; liver steatosis; insulin resistance; obesity; INSULIN SENSITIVITY; PEDIATRIC GASTROENTEROLOGY; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; HEPATIC STEATOSIS; FIBROSIS; WOMEN; CHILDREN; NAFLD; RESISTANCE;
D O I
10.3390/jcm12020557
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of this case-control study was to assess the burden of non-alcoholic fatty liver disease (NAFLD) in adolescents with polycystic ovary syndrome (PCOS) and its associations with insulin resistance, hyperandrogenism, and other metabolic characteristics of the syndrome. A total of 87 Caucasian adolescent girls (47 with PCOS and 40 controls), aged 12.3-20.4 years, underwent blood sampling for glucose metabolism, hormonal and lipid profile, gynecological and liver ultrasound, and liver elastography. Indices of insulin resistance, liver steatosis, and liver fibrosis were calculated. NAFLD diagnosed by ultrasound was more prevalent in adolescents with PCOS than controls (22.7% vs. 6.1%, p = 0.046), and was also verified by liver steatosis indices. The latter was not apparent for hepatic fibrosis, as assessed by Fibroscan((R)) and calculated indices. The homeostatic model assessment for insulin resistance (HOMA-IR) was found to predict NAFLD diagnosis by the liver fat score (LFS) index (beta = 0.709, p = 0.002). Adolescents with PCOS and high free androgen index (FAI) presented worse NAFLD than those adolescents with PCOS and lower FAI. In addition, adolescents with PCOS and concurrent NAFLD had worse insulin sensitivity indices (HOMA-IR, QUICKI, and glucose to insulin ratio) than adolescents with PCOS alone. Adolescent insulin resistance could be considered a confounder of the association between PCOS and NAFLD.
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页数:13
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